Development and characterization of novel erythropoiesis stimulating protein (NESP)

Studies on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid‐containing carbohydrate content of the molecule and its serum half‐life and in vivo biological activity, but an inverse relationship with its receptor binding affinity. These observations l...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2001-01, Vol.16 (suppl-3), p.3-13
Hauptverfasser:	Egrie, Joan C., Browne, Jeffrey K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biological activity carbohydrate Darbepoetin alfa erythropoietin Erythropoietin - analogs & derivatives Erythropoietin - biosynthesis Erythropoietin - chemistry Erythropoietin - pharmacology Erythropoietin - therapeutic use Glycosylation Hematocrit Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - therapy Molecular Structure pharmacokinetics Protein Isoforms Recombinant Proteins Renal Replacement Therapy review
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