Interaction between dna-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid

Recent studies have indicated that there are many barriers to successful systemic gene delivery via cationic lipid vectors using the intravenous route. The purpose of this study was to investigate the effect of binding and interaction between erythrocytes, a major constituent of blood cells, and the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gene therapy 2001-05, Vol.8 (9), p.677-686
Hauptverfasser:	SAKURAI, F, NISHIOKA, T, SAITO, H, BABA, T, OKUDA, A, MATSUMOTO, O, TAGA, T, YAMASHITA, F, TAKAKURA, Y, HASHIDA, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Blood Proteins - metabolism Chemical Phenomena Chemistry, Physical Deoxyribonucleic acid Diphenylhexatriene - chemistry DNA DNA - metabolism DOPE DOTMA Erythrocytes Erythrocytes - metabolism Fluidity Fluorescence Polarization Fundamental and applied biological sciences. Psychology Gene expression Gene therapy Gene transfer Gene Transfer Techniques Genetic Vectors - administration & dosage Glycerophospholipids - chemistry Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Injections, Intravenous Intravenous administration Lipid Metabolism Lipids Lipids - chemistry Liposomes Liposomes - metabolism Lung - cytology Mice Microscopy, Atomic Force Phosphatidylethanolamines Quaternary Ammonium Compounds - chemistry Structure-Activity Relationship Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!