A novel mechanism associated with idiopathic ventricular fibrillation (IVF) mutations R1232W and T1620M in human cardiac sodium channels

Two mutations associated with idiopathic ventricular fibrillation (IVF) are localized within extracellular loops between segments DIIIS1-S2 (R1232W) and DIVS3-S4 (T1620M) of the human cardiac sodium channel (hNav1.5) alpha-subunit. We studied wild-type hNav1.5 channels and hNav1.5 channels with the...

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Veröffentlicht in:	Pflügers Archiv 2001-05, Vol.442 (2), p.204-211
Hauptverfasser:	Vilin, Y Y, Fujimoto, E, Ruben, P C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Electrophysiology Homeostasis Humans Kinetics Mutation - physiology Myocardium - metabolism NAV1.5 Voltage-Gated Sodium Channel Oocytes Sodium Channels - genetics Sodium Channels - physiology Time Factors Ventricular Fibrillation - genetics Xenopus laevis
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