A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation

Previous evidence suggests that interactions between integrin cytoplasmic domains regulate integrin activation. We have constructed and validated recombinant structural mimics of the heterodimeric alpha(IIb)beta(3) cytoplasmic domain. The mimics elicited polyclonal antibodies that recognize a combin...

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Veröffentlicht in:	The Journal of biological chemistry 2001-06, Vol.276 (25), p.22514-22521
Hauptverfasser:	Ginsberg, M H, Yaspan, B, Forsyth, J, Ulmer, T S, Campbell, I D, Slepak, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Membrane - metabolism Cytoplasm - metabolism Enzyme-Linked Immunosorbent Assay Integrins - chemistry Integrins - metabolism Molecular Sequence Data Recombinant Proteins - chemistry Recombinant Proteins - metabolism
Online-Zugang:	Volltext
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