Colonic Mucosal Concentrations of Folate Are Accurately Predicted by Blood Measurements of Folate Status among Individuals Ingesting Physiologic Quantities of Folate
Folate status is inversely related to the risk of colorectal cancer. Whether conventional blood measurements of folate status accurately reflect folate concentrations in the colorectal mucosa has been a controversial topic. This is an important issue because accurate measures of folate status in the...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2001-06, Vol.10 (6), p.715-719 |
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| creator | KIM, Young-In FAWAZ, Karim KNOX, Tamsin LEE, Young-Mee NORTON, Richard LIBBY, Eric MASON, Joel B |
| description | Folate status is inversely related to the risk of colorectal cancer. Whether conventional blood measurements of folate status
accurately reflect folate concentrations in the colorectal mucosa has been a controversial topic. This is an important issue
because accurate measures of folate status in the colorectal mucosa are important for ascertaining the risk of colorectal
cancer in epidemiological studies and for determining the effects of folate supplementation in clinical trials. We examined
whether conventional blood measurements of folate and a more sensitive, inverse indicator of systemic folate status, serum
homocysteine, accurately reflect folate concentrations in human colonic mucosa obtained by endoscopic biopsy. Study subjects
( n = 20) were participants in a randomized trial that investigated the effect of folate supplementation (5 mg daily for 1 year)
on provisional molecular markers of colon cancer. Blood samples and biopsies of normal rectosigmoid mucosa were obtained at
baseline, at 6 months, and at 1 year. Serum, RBC, and colonic mucosal folate and serum homocysteine concentrations were determined.
Colonic mucosal folate concentrations correlated directly with serum folate concentrators at each time point ( r = 0.572–0.845; P < 0.015) and with RBC folate concentrations at 6 months and 1 year ( r = 0.747–0.771; P < 0.001). Colonic mucosal folate concentrations correlated inversely with serum homocysteine concentrations at each time
point ( r = −0.622–0.666; P < 0.008). Systemic measures of folate status did not correlate with colonic mucosal folate concentrations among individuals
receiving supplemental folate. Our observations indicate that colonic mucosal concentrations of folate may be predicted accurately
by blood measurements of folate status only among individuals not ingesting supraphysiological quantities of folate. |
| format | Article |
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accurately reflect folate concentrations in the colorectal mucosa has been a controversial topic. This is an important issue
because accurate measures of folate status in the colorectal mucosa are important for ascertaining the risk of colorectal
cancer in epidemiological studies and for determining the effects of folate supplementation in clinical trials. We examined
whether conventional blood measurements of folate and a more sensitive, inverse indicator of systemic folate status, serum
homocysteine, accurately reflect folate concentrations in human colonic mucosa obtained by endoscopic biopsy. Study subjects
( n = 20) were participants in a randomized trial that investigated the effect of folate supplementation (5 mg daily for 1 year)
on provisional molecular markers of colon cancer. Blood samples and biopsies of normal rectosigmoid mucosa were obtained at
baseline, at 6 months, and at 1 year. Serum, RBC, and colonic mucosal folate and serum homocysteine concentrations were determined.
Colonic mucosal folate concentrations correlated directly with serum folate concentrators at each time point ( r = 0.572–0.845; P < 0.015) and with RBC folate concentrations at 6 months and 1 year ( r = 0.747–0.771; P < 0.001). Colonic mucosal folate concentrations correlated inversely with serum homocysteine concentrations at each time
point ( r = −0.622–0.666; P < 0.008). Systemic measures of folate status did not correlate with colonic mucosal folate concentrations among individuals
receiving supplemental folate. Our observations indicate that colonic mucosal concentrations of folate may be predicted accurately
by blood measurements of folate status only among individuals not ingesting supraphysiological quantities of folate.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 11401925</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adenoma - drug therapy ; Adult ; Biological and medical sciences ; Colonic Neoplasms - drug therapy ; Diet ; Dietary Supplements ; Female ; Folic Acid - administration & dosage ; Folic Acid - analysis ; Folic Acid - blood ; Gastroenterology. Liver. Pancreas. Abdomen ; Hematinics - administration & dosage ; Hematinics - analysis ; Hematinics - blood ; Homocysteine - blood ; Humans ; Intestinal Mucosa - chemistry ; Male ; Medical sciences ; Reproducibility of Results ; Sensitivity and Specificity ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2001-06, Vol.10 (6), p.715-719</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14135953$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11401925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIM, Young-In</creatorcontrib><creatorcontrib>FAWAZ, Karim</creatorcontrib><creatorcontrib>KNOX, Tamsin</creatorcontrib><creatorcontrib>LEE, Young-Mee</creatorcontrib><creatorcontrib>NORTON, Richard</creatorcontrib><creatorcontrib>LIBBY, Eric</creatorcontrib><creatorcontrib>MASON, Joel B</creatorcontrib><title>Colonic Mucosal Concentrations of Folate Are Accurately Predicted by Blood Measurements of Folate Status among Individuals Ingesting Physiologic Quantities of Folate</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Folate status is inversely related to the risk of colorectal cancer. Whether conventional blood measurements of folate status
accurately reflect folate concentrations in the colorectal mucosa has been a controversial topic. This is an important issue
because accurate measures of folate status in the colorectal mucosa are important for ascertaining the risk of colorectal
cancer in epidemiological studies and for determining the effects of folate supplementation in clinical trials. We examined
whether conventional blood measurements of folate and a more sensitive, inverse indicator of systemic folate status, serum
homocysteine, accurately reflect folate concentrations in human colonic mucosa obtained by endoscopic biopsy. Study subjects
( n = 20) were participants in a randomized trial that investigated the effect of folate supplementation (5 mg daily for 1 year)
on provisional molecular markers of colon cancer. Blood samples and biopsies of normal rectosigmoid mucosa were obtained at
baseline, at 6 months, and at 1 year. Serum, RBC, and colonic mucosal folate and serum homocysteine concentrations were determined.
Colonic mucosal folate concentrations correlated directly with serum folate concentrators at each time point ( r = 0.572–0.845; P < 0.015) and with RBC folate concentrations at 6 months and 1 year ( r = 0.747–0.771; P < 0.001). Colonic mucosal folate concentrations correlated inversely with serum homocysteine concentrations at each time
point ( r = −0.622–0.666; P < 0.008). Systemic measures of folate status did not correlate with colonic mucosal folate concentrations among individuals
receiving supplemental folate. Our observations indicate that colonic mucosal concentrations of folate may be predicted accurately
by blood measurements of folate status only among individuals not ingesting supraphysiological quantities of folate.</description><subject>Adenoma - drug therapy</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Folic Acid - administration & dosage</subject><subject>Folic Acid - analysis</subject><subject>Folic Acid - blood</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hematinics - administration & dosage</subject><subject>Hematinics - analysis</subject><subject>Hematinics - blood</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Intestinal Mucosa - chemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkc1u1TAQhSNERUvhFZA30FUk_8bxslxRqNSKVsA6mjiTG6PELv4B3QfiPWupF9GFNSPPd84c2S-aM6ZE32qt1MvaU6VaYzp12rxO6SelVBulXjWnjEnKDFdnzd9dWIN3ltwWGxKsZBe8RZ8jZBd8ImEmV2GFjOQy1mNtqRNcD-Qu4uRsxomMB_JxDWEitwipRNyq_LnwW4ZcEoEt-D259pP77aYCa6r9HlN29fZuOSRXg-xrkPsCPrvs8JnHm-Zkrgp8e6znzY-rT993X9qbr5-vd5c37cI7k1sEITuptRUzt8yIvpejknKkPR-tRjXNPbUd50IggDZcoGWS9bKDiaOiUpw3H558H2L4VWq4YXPJ4rqCx1DSoKnhpm6o4LsjWMYNp-Ehug3iYfj3sBV4fwQgWVjnCN669J-TTCijROUunrjF7Zc_LuJgK4kxYkKIdhkYHbpB1199BN3Ckvo</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>KIM, Young-In</creator><creator>FAWAZ, Karim</creator><creator>KNOX, Tamsin</creator><creator>LEE, Young-Mee</creator><creator>NORTON, Richard</creator><creator>LIBBY, Eric</creator><creator>MASON, Joel B</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Colonic Mucosal Concentrations of Folate Are Accurately Predicted by Blood Measurements of Folate Status among Individuals Ingesting Physiologic Quantities of Folate</title><author>KIM, Young-In ; FAWAZ, Karim ; KNOX, Tamsin ; LEE, Young-Mee ; NORTON, Richard ; LIBBY, Eric ; MASON, Joel B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-ea346477c3f2c193884b544b082bc7e5df80c62233eaa7923ec141846ad2e5043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adenoma - drug therapy</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Folic Acid - administration & dosage</topic><topic>Folic Acid - analysis</topic><topic>Folic Acid - blood</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hematinics - administration & dosage</topic><topic>Hematinics - analysis</topic><topic>Hematinics - blood</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Intestinal Mucosa - chemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIM, Young-In</creatorcontrib><creatorcontrib>FAWAZ, Karim</creatorcontrib><creatorcontrib>KNOX, Tamsin</creatorcontrib><creatorcontrib>LEE, Young-Mee</creatorcontrib><creatorcontrib>NORTON, Richard</creatorcontrib><creatorcontrib>LIBBY, Eric</creatorcontrib><creatorcontrib>MASON, Joel B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIM, Young-In</au><au>FAWAZ, Karim</au><au>KNOX, Tamsin</au><au>LEE, Young-Mee</au><au>NORTON, Richard</au><au>LIBBY, Eric</au><au>MASON, Joel B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colonic Mucosal Concentrations of Folate Are Accurately Predicted by Blood Measurements of Folate Status among Individuals Ingesting Physiologic Quantities of Folate</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>10</volume><issue>6</issue><spage>715</spage><epage>719</epage><pages>715-719</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Folate status is inversely related to the risk of colorectal cancer. Whether conventional blood measurements of folate status
accurately reflect folate concentrations in the colorectal mucosa has been a controversial topic. This is an important issue
because accurate measures of folate status in the colorectal mucosa are important for ascertaining the risk of colorectal
cancer in epidemiological studies and for determining the effects of folate supplementation in clinical trials. We examined
whether conventional blood measurements of folate and a more sensitive, inverse indicator of systemic folate status, serum
homocysteine, accurately reflect folate concentrations in human colonic mucosa obtained by endoscopic biopsy. Study subjects
( n = 20) were participants in a randomized trial that investigated the effect of folate supplementation (5 mg daily for 1 year)
on provisional molecular markers of colon cancer. Blood samples and biopsies of normal rectosigmoid mucosa were obtained at
baseline, at 6 months, and at 1 year. Serum, RBC, and colonic mucosal folate and serum homocysteine concentrations were determined.
Colonic mucosal folate concentrations correlated directly with serum folate concentrators at each time point ( r = 0.572–0.845; P < 0.015) and with RBC folate concentrations at 6 months and 1 year ( r = 0.747–0.771; P < 0.001). Colonic mucosal folate concentrations correlated inversely with serum homocysteine concentrations at each time
point ( r = −0.622–0.666; P < 0.008). Systemic measures of folate status did not correlate with colonic mucosal folate concentrations among individuals
receiving supplemental folate. Our observations indicate that colonic mucosal concentrations of folate may be predicted accurately
by blood measurements of folate status only among individuals not ingesting supraphysiological quantities of folate.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>11401925</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenoma - drug therapy Adult Biological and medical sciences Colonic Neoplasms - drug therapy Diet Dietary Supplements Female Folic Acid - administration & dosage Folic Acid - analysis Folic Acid - blood Gastroenterology. Liver. Pancreas. Abdomen Hematinics - administration & dosage Hematinics - analysis Hematinics - blood Homocysteine - blood Humans Intestinal Mucosa - chemistry Male Medical sciences Reproducibility of Results Sensitivity and Specificity Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Colonic Mucosal Concentrations of Folate Are Accurately Predicted by Blood Measurements of Folate Status among Individuals Ingesting Physiologic Quantities of Folate |
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