Oral delivery of taxanes

Oral treatment with cytotoxic agents is to be preferred as this administration route is convenient to patients, reduces administration costs and facilitates the use of more chronic treatment regimens. For the taxanes paclitaxel and docetaxel, however, low oral bioavailability has limited development...

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Veröffentlicht in:	Investigational new drugs 2001-05, Vol.19 (2), p.155-162
Hauptverfasser:	Malingré, M M, Beijnen, J H, Schellens, J H
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors Bioavailability Biological Availability Cancer therapies Cell cycle Cyclosporine - administration & dosage Cyclosporins - administration & dosage Cytochrome Cytotoxicity Drug dosages Glycoproteins Humans Metabolism Mice Mice, Knockout Neoplasms - drug therapy Oral administration Paclitaxel - administration & dosage Paclitaxel - analogs & derivatives Paclitaxel - pharmacokinetics Patients Pharmacokinetics Quality of life Rodents Signal transduction Taxoids
Online-Zugang:	Volltext
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