Conversion of cyclic nonaketides to lovastatin and compactin by a lovc deficient mutant of Aspergillus terreus

Investigation of the post-PKS biosynthetic steps to the cholesterol-lowering agent lovastatin ( 1) using an Aspergillus terreus strain with a disrupted lovC gene, which is essential for formation of 4a,5-dihydromonacolin L ( 3), shows that 7 and 3 are precursors to 1, and demonstrates that lovastati...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-06, Vol.11 (12), p.1527-1531
Hauptverfasser:	Auclair, Karine, Kennedy, Jonathan, Hutchinson, C.Richard, Vederas, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticholesteremic Agents - metabolism Aspergillus - enzymology Aspergillus - genetics Aspergillus - metabolism Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Fungal Proteins Health. Pharmaceutical industry Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism Industrial applications and implications. Economical aspects Lovastatin - analogs & derivatives Lovastatin - biosynthesis Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Other active biomolecules Production of active biomolecules
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Zusammenfassung:	Investigation of the post-PKS biosynthetic steps to the cholesterol-lowering agent lovastatin ( 1) using an Aspergillus terreus strain with a disrupted lovC gene, which is essential for formation of 4a,5-dihydromonacolin L ( 3), shows that 7 and 3 are precursors to 1, and demonstrates that lovastatin diketide synthase ( lovF protein) does not require lovC. Graphic
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(01)00290-6