DNA Alkylation by leinamycin can be triggered by cyanide and phosphines

Previous work has shown that alkylation of DNA by the antitumor agent leinamycin ( 1) is potentiated by reaction of the antibiotic with thiols. Here, it is shown that other soft nucleophiles such as cyanide and phosphines can also trigger DNA alkylation by leinamycin. Overall, the results suggest th...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-06, Vol.11 (12), p.1511-1515
Hauptverfasser:	Zang, Hong, Breydo, Leonid, Mitra, Kaushik, Dannaldson, Jeffrey, Gates, Kent S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation - drug effects Antibiotics, Antineoplastic - metabolism Antineoplastic agents Biological and medical sciences Cyanides - pharmacology DNA - chemistry DNA - metabolism DNA Damage - drug effects Electrophoresis, Polyacrylamide Gel General aspects Lactams Macrolides Medical sciences Oligonucleotides - chemistry Oligonucleotides - metabolism Pharmacology. Drug treatments Phosphines - pharmacology Plasmids - chemistry Plasmids - metabolism Thiazoles Thiones
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