Up-regulation of tumor necrosis factor-alpha and interferon-gamma expression in the spleen and lungs of mice infected with the human Babesia isolate WA1

We analyzed cytokine expression in mice infected with the intraerythrocytic parasites Babesia microti and WA1. In C3H/HeN mice, WA1 infections were fatal, whereas B. microti infections were resolved. We propose that the proinflammatory cytokines tumor necrosis factor-alpha (TNFalpha) and interferon-...

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Veröffentlicht in:	Parasitology research (1987) 2000-02, Vol.86 (2), p.121-128
Hauptverfasser:	HEMMER, R. M, FERRICK, D. A, CONRAD, P. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Babesiosis - etiology Babesiosis - immunology Babesiosis - mortality Biological and medical sciences Experimental protozoal diseases and models Female Humans Infectious diseases Interferon-gamma - biosynthesis Interleukin-10 - biosynthesis Interleukin-4 - biosynthesis Lung - immunology Medical sciences Mice Mice, Inbred C3H Parasitemia - etiology Parasitemia - immunology Parasitemia - mortality Parasitic diseases Protozoal diseases Spleen - immunology Tumor Necrosis Factor-alpha - biosynthesis Up-Regulation
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