Elevated levels of Ca(II) modulate the activity and inhibition of serine proteases: implication in the mechanism of apoptosis

Elevated levels of intracellular Ca(II) are a prominent feature of apoptosis, a natural form of cell death involved in many physiological and pathological processes. Serine proteases play crucial roles in apoptosis and have been implicated in the genomic DNA degradation and the massive protein degra...

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Veröffentlicht in:	Cell biochemistry and function 2000-01, Vol.18 (1), p.59-66
Hauptverfasser:	Adebodun, Foluso, Scott, Corey E., Cunningham, Connell, Bustamante, Pedro M., Bradshaw, Ayanna, Ping, Liu, Williams, Karen R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Calcimycin - pharmacology Calcium - pharmacology Chymotrypsin - metabolism Dexamethasone - pharmacology Edetic Acid - pharmacology effects of calcium ions enzyme inhibition Enzyme Stability glucocorticoid action Ionophores - pharmacology leukemic cells Magnesium - pharmacology Potassium - pharmacology Serine Endopeptidases - metabolism serine proteases serine proteinase Serine Proteinase Inhibitors - pharmacology Sodium - pharmacology Trypsin - metabolism Tumor Cells, Cultured
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