Multivalent DNA-Based Immunization against Hepatitis B Virus with Plasmids Encoding Surface and Core Antigens

The immune response against hepatitis B surface and core antigens was evaluated by either coinoculation or independent intramuscular administration of pAEC compact DNA immunization vectors carrying their genes. The pAEC vectors bear just the essential elements for mammalian expression and bacterial...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-03, Vol.282 (2), p.442-446
Hauptverfasser:	Musacchio, Alexis, Rodriguez, Ernesto G., Herrera, Antonieta M., Quintana, Diógenes, Muzio, Verena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence COS Cells DNA immunization Female Genetic Vectors HBcAg HBsAg hepatitis B Hepatitis B Antibodies - biosynthesis Hepatitis B Core Antigens - genetics Hepatitis B Core Antigens - immunology hepatitis B surface antigen Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - immunology hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Immunization Lymphocyte Activation Mice Mice, Inbred BALB C Plasmids - genetics T-Lymphocytes - immunology Transfection Vaccines, DNA - genetics Vaccines, DNA - immunology Vaccines, DNA - pharmacology
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