Phosphatidylinositol 3-kinase-dependent stabilization of alpha1(I) collagen mRNA in human lung fibroblasts

We investigated the role of phosphatidylinositol 3-kinase (PI3K) in the expression of alpha1(I) collagen mRNA. We report that the basal level of alpha1(I) collagen mRNA was reduced when PI3K activity was inhibited by either LY-294002 or wortmannin. These PI3K inhibitors also blocked increases of alp...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2001-07, Vol.281 (1), p.C99-C105
Hauptverfasser:	Ricupero, D A, Poliks, C F, Rishikof, D C, Cuttle, K A, Kuang, P P, Goldstein, R H
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Androstadienes - pharmacology Animals Blotting, Northern Cells, Cultured Chromones - pharmacology Collagen - genetics Collagen - metabolism Cycloheximide - pharmacology Dactinomycin - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Fibroblasts - metabolism Gene Expression Regulation Humans Immunoblotting Kinetics Lung - cytology Mice Morpholines - pharmacology Nucleic Acid Synthesis Inhibitors - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Protein Synthesis Inhibitors - pharmacology Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt RNA Stability - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Transfection
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