High-throughput and ultra-high-throughput screening: solution- and cell-based approaches
The trend towards assay miniaturization for high-throughput and ultra-high-throughput screening continues to spur development of homogeneous, fluorescence-based assays in higher density, smaller volume microplate formats. Recently, first-generation microfluidic devices have been designed for perform...
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| Veröffentlicht in: | Current Opinion in Biotechnology 2000-02, Vol.11 (1), p.47-53 |
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| container_title | Current Opinion in Biotechnology |
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| creator | Sundberg, Steven A |
| description | The trend towards assay miniaturization for high-throughput and ultra-high-throughput screening continues to spur development of homogeneous, fluorescence-based assays in higher density, smaller volume microplate formats. Recently, first-generation microfluidic devices have been designed for performing continuous-flow biochemical and cell-based assays. These devices provide orders-of-magnitude reduction in reagent consumption, and offer the potential for implementing high-throughput screening in formats that integrate up-front compound handling with unique assay functionality. |
| doi_str_mv | 10.1016/S0958-1669(99)00051-8 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Current Opinion in Biotechnology, 2000-02, Vol.11 (1), p.47-53 |
| issn | 0958-1669 1879-0429 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biotechnology - instrumentation Biotechnology - methods Cells - enzymology Cells - metabolism Drug Evaluation, Preclinical - methods Enzymes - metabolism Fluorescence high-throughput screening Humans Ligands Microchemistry - instrumentation Microchemistry - methods Protein Binding Solutions |
| title | High-throughput and ultra-high-throughput screening: solution- and cell-based approaches |
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