Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein

Human T-cell leukemia virus type 1 (HTLV-1) establishes a persistent infection in the host despite a vigorous virus-specific immune response. Here we demonstrate that an HTLV-1-encoded protein, p12(I), resides in the endoplasmic reticulum (ER) and Golgi and physically binds to the free human major h...

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Veröffentlicht in:	Journal of virology 2001-07, Vol.75 (13), p.6086-6094
Hauptverfasser:	Johnson, J M, Nicot, C, Fullen, J, Ciminale, V, Casareto, L, Mulloy, J C, Jacobson, S, Franchini, G
Format:	Artikel
Sprache:	eng
Schlagworte:	beta 2-Microglobulin - metabolism Biological Transport Cysteine Endopeptidases - physiology Endoplasmic Reticulum - metabolism Golgi Apparatus - metabolism HeLa Cells Histocompatibility Antigens Class I - metabolism HLA-A2 Antigen - metabolism HLA-B7 Antigen - metabolism HLA-C Antigens - metabolism Humans Multienzyme Complexes - physiology Oncogene Proteins, Viral - physiology Proteasome Endopeptidase Complex Transcription Factors Viral Regulatory and Accessory Proteins
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