A gene expression database for the molecular pharmacology of cancer

We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell lines used in a drug discovery screen by the National Cancer Institute. Using these data, we linked bioinformatics and chemoinformatics by correlating gene expression and drug activity patterns in the NCI60 lines. Cl...

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Veröffentlicht in:	Nature genetics 2000-03, Vol.24 (3), p.236-244
Hauptverfasser:	Scherf, Uwe, Ross, Douglas T., Waltham, Mark, Smith, Lawrence H., Lee, Jae K., Tanabe, Lorraine, Kohn, Kurt W., Reinhold, William C., Myers, Timothy G., Andrews, Darren T., Scudiero, Dominic A., Eisen, Michael B., Sausville, Edward A., Pommier, Yves, Botstein, David, Brown, Patrick O., Weinstein, John N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Antineoplastic agents Antineoplastic Agents - classification Antineoplastic Agents - pharmacology Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cluster Analysis Databases, Factual DNA, Complementary - genetics DNA, Neoplasm - genetics Drug Resistance, Neoplasm - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Gene Function General aspects Genetic aspects Human Genetics Humans L-^Aasparaginase Medical sciences Molecular and cellular biology Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oligonucleotide Array Sequence Analysis Organ Specificity Pharmacology Pharmacology. Drug treatments Physiological aspects Tumor Cells, Cultured - classification Tumor Cells, Cultured - metabolism
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