In vitro IgE inhibition in B cells by anti-CD23 monoclonal antibodies is functionally dependent on the immunoglobulin Fc domain

CD23, the low affinity receptor for IgE (FcεRII), is involved in regulation of IgE synthesis by B-lymphocytes. Five monoclonal antibodies to human CD23 were generated from cynomolgus macaques immunized with purified soluble CD23 (sCD23). Four of the five primate antibodies blocked the binding of IgE...

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Veröffentlicht in:	International journal of immunopharmacology 2000-02, Vol.22 (2), p.131-141
Hauptverfasser:	Nakamura, Takehiko, Kloetzer, William S, Brams, Peter, Hariharan, Kandasamy, Chamat, Soulaima, Cao, Xianjun, LaBarre, Michael J, Chinn, Paul C, Morena, Ron A, Shestowsky, William S, Li, Yan-Ping, Chen, Agnes, Reff, Mitchell E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology B-Lymphocytes - immunology Biological and medical sciences CD23 antigen Histamine and antagonists. Allergy Humans Immunoglobulin E - biosynthesis Immunoglobulin Fc Fragments - physiology Macaca fascicularis Medical sciences Pharmacology. Drug treatments Receptors, IgE - physiology
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