Substrate recognition by UDP-galactose and CMP-sialic acid transporters. Different sets of transmembrane helices are utilized for the specific recognition of UDP-galactose and CMP-sialic acid

Human UDP-galactose transporter (hUGT1) and CMP-sialic acid transporter (hCST) are related Golgi membrane proteins with 10 transmembrane helices. We have constructed chimeras between these proteins in order to identify submolecular regions responsible for the determination of substrate specificity....

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Veröffentlicht in:	The Journal of biological chemistry 2001-06, Vol.276 (24), p.21555-21561
Hauptverfasser:	Aoki, K, Ishida, N, Kawakita, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Carrier Proteins - chemistry Carrier Proteins - metabolism Cell Line CHO Cells Cricetinae Cytidine Monophosphate N-Acetylneuraminic Acid - metabolism DNA, Complementary Golgi Apparatus - metabolism Humans Intracellular Membranes - metabolism Kinetics Lectins - metabolism Membrane Proteins - chemistry Membrane Proteins - metabolism Molecular Sequence Data Monosaccharide Transport Proteins - chemistry Monosaccharide Transport Proteins - metabolism Nucleotide Transport Proteins Protein Structure, Secondary Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Substrate Specificity Transfection Uridine Diphosphate Galactose - metabolism
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