Specific activation of the alpha 7 nicotinic acetylcholine receptor by a quaternary analog of cocaine

Effects of cocaine and cocaine methiodide were evaluated on the homomeric alpha 7 neuronal nicotinic receptor (nAChR). Whereas cocaine itself is a general nAChR noncompetitive antagonist, we report here the characterization of cocaine methiodide, a novel selective agonist for the alpha 7 subtype of...

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Veröffentlicht in:	Molecular pharmacology 2001-07, Vol.60 (1), p.71-79
Hauptverfasser:	Francis, M M, Cheng, E Y, Weiland, G A, Oswald, R E
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha7 Nicotinic Acetylcholine Receptor Animals Binding, Competitive Bungarotoxins - pharmacology Cocaine - analogs & derivatives Cocaine - pharmacology Dimerization Iodine Radioisotopes Oocytes - drug effects Oocytes - metabolism PC12 Cells Rats Receptors, Nicotinic - drug effects Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism Transfection Xenopus laevis
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