Acute behavioral and EEG effects of NW-1015 on electrically-induced afterdischarge in conscious monkeys

NW-1015 is a novel Na + and Ca 2+ channel blocker with broad spectrum anticonvulsant activity and an excellent safety margin. As the compound also shows sigma-1 receptor ligand properties it was deemed important to determine whether it possesses anticonvulsant properties in primates without causing...

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Veröffentlicht in:	Epilepsy research 2000-03, Vol.39 (1), p.37-46
Hauptverfasser:	Fariello, R.G, Maj, R, Marrari, P, Beard, D, Algate, C, Salvati, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Afterdischarge Alanine - analogs & derivatives Alanine - blood Alanine - pharmacology Alanine - therapeutic use Animals Anticonvulsant Anticonvulsants - blood Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Behavior, Animal - drug effects Benzylamines - blood Benzylamines - pharmacology Benzylamines - therapeutic use Biological and medical sciences Electric Stimulation Electroencephalography - drug effects Epilepsy Macaca fascicularis Male Medical sciences Monkeys Neuropharmacology NW-1015 Pharmacology. Drug treatments Phenytoin - blood Phenytoin - pharmacology Phenytoin - therapeutic use Seizures - drug therapy
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