Oxidized Low Density Lipoproteins Regulate Synthesis of Monkey Aortic Smooth Muscle Cell Proteoglycans That Have Enhanced Native Low Density Lipoprotein Binding Properties

Oxidized low density lipoproteins (Ox-LDL) affect several biological processes involved in atherogenesis. However, it is not known whether Ox-LDL can regulate proteoglycan expression and thus affect arterial wall lipoprotein retention. This study evaluated whether Ox-LDL, as compared with native LDL...

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Veröffentlicht in:	The Journal of biological chemistry 2000-02, Vol.275 (7), p.4766-4773
Hauptverfasser:	Chang, Mary Y., Potter-Perigo, Susan, Tsoi, Christina, Chait, Alan, Wight, Thomas N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aorta Aorta, Thoracic - cytology Aorta, Thoracic - metabolism Arteriosclerosis - metabolism biglycan binding cell lines Cells, Cultured decorin gene expression Glucosamine - metabolism glycosaminoglycans Glycosaminoglycans - chemistry Glycosaminoglycans - metabolism Lipoproteins, LDL - metabolism low density lipoprotein Macaca nemestrina messenger RNA molecular weight monkeys Muscle, Smooth - cytology Muscle, Smooth - metabolism oxidation Protein Binding protein synthesis proteoglycans Proteoglycans - metabolism regulation smooth muscle Sulfuric Acids - metabolism versican
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