Development of the interstitial cell of Cajal: origin, Kit dependence and neuronal and nonneuronal sources of Kit ligand

Kit is a marker for interstitial cells of Cajal (ICC). ICCs interact with enteric neurons and are essential for gastrointestinal motility. The roles of neural crest‐derived cells, neurons, Kit, and Kit ligand (KL) in ICC development were analyzed. ICC development lagged behind that of neurons and sm...

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Veröffentlicht in:	Journal of neuroscience research 2000-02, Vol.59 (3), p.384-401
Hauptverfasser:	Wu, Jun J., Rothman, Taube P., Gershon, Michael D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Antibodies - pharmacology Cell Differentiation - physiology Cellular Senescence - physiology Colon - cytology Colon - embryology Digestive System - cytology Digestive System - embryology Digestive System - metabolism Drosophila Proteins endothelin-3 Endothelin-3 - physiology gut Intestinal Mucosa - metabolism Intestines - cytology Intestines - embryology Intestines - innervation mesoderm mesoderm, gut Mice Mice, Inbred Strains Mice, Mutant Strains - genetics neural crest Neural Crest - cytology Neural Crest - drug effects Neurons - metabolism Organ Culture Techniques Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases - genetics Receptor, Nerve Growth Factor - immunology Reference Values Ret Stem Cell Factor - metabolism Stem Cell Factor - physiology Stem Cells - cytology
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