Effect of probucol in a murine model of slowly progressive polycystic kidney disease

Epithelial proliferation, extracellular matrix remodeling, and interstitial inflammation are central elements in the pathogenesis of slowly progressive polycystic kidney disorders. Probucol, an antioxidant that lowers plasma cholesterol, has been shown to decrease smooth muscle cell proliferation an...

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Veröffentlicht in:	American journal of kidney diseases 2000-02, Vol.35 (2), p.221-226
Hauptverfasser:	Nagao, Shizuko, Yamaguchi, Tamio, Kasahara, Masao, Kusaka, Masatomo, Matsuda, Jun, Ogiso, Noboru, Takahashi, Hisahide, Grantham, Jared J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - therapeutic use antioxidant Biological and medical sciences cell proliferation cholesterol Disease Models, Animal Disease Progression lovastatin Male Medical sciences Mice Mice, Inbred C57BL Mice, Inbred DBA Pharmacology. Drug treatments Polycystic kidney disease (PKD) Polycystic Kidney Diseases - drug therapy Probucol - therapeutic use Ras proteins Time Factors Urinary system
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