Functional balance between T cell chimeric receptor density and tumor associated antigen density : CTL mediated cytolysis and lymphokine production

Genetically engineered expression of tumor-specific single chain antibody chimeric receptors (ch-Rec) on human T lymphocytes endow these cells with the parental monoclonal antibody (mAb) dictated tumor specificity and may be useful for clinical immuno-genetherapy. Therefore it was of importance to a...

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