Births of freemartins derived from embryos reconstructed with ear fibroblasts
Although the combination of artificial insemination (AI) and embryo transfer (ET) is effective for preventing large offspring syndrome in clone cattle production, it may cause freemartinism. In this study, 51 reconstructed embryos were transferred to artificially inseminated recipients. Of those 9 t...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2001, Vol.63(5), pp.577-578 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | Hwang, W.S. (Seoul National Univ., Suwon (Korea R.)) Cho, J.K Kim, K.Y Shin, S.J Kim, S.K Park, J.I Kim. D.Y Lee, J.K Lim, J.M Lee, B.C |
| description | Although the combination of artificial insemination (AI) and embryo transfer (ET) is effective for preventing large offspring syndrome in clone cattle production, it may cause freemartinism. In this study, 51 reconstructed embryos were transferred to artificially inseminated recipients. Of those 9 twin pregnancies, three delivered male and female offsprings. The females had tufts of long coarse hair and short blind pouch at the vaginal end. At necropsy, hypoplastic testicles and epididymis, which connected to the uterus through the spermatic cord, were found and seminal vesicles were also noted. All females had mixed sex chromosome configuration (60, XX and 60, XY). These results suggest that the combined ET program can cause freemartinism, which reduces the efficiency of clone cattle production. |
| doi_str_mv | 10.1292/jvms.63.577 |
| format | Article |
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(Seoul National Univ., Suwon (Korea R.)) ; Cho, J.K ; Kim, K.Y ; Shin, S.J ; Kim, S.K ; Park, J.I ; Kim. D.Y ; Lee, J.K ; Lim, J.M ; Lee, B.C</creator><creatorcontrib>Hwang, W.S. (Seoul National Univ., Suwon (Korea R.)) ; Cho, J.K ; Kim, K.Y ; Shin, S.J ; Kim, S.K ; Park, J.I ; Kim. D.Y ; Lee, J.K ; Lim, J.M ; Lee, B.C</creatorcontrib><description>Although the combination of artificial insemination (AI) and embryo transfer (ET) is effective for preventing large offspring syndrome in clone cattle production, it may cause freemartinism. In this study, 51 reconstructed embryos were transferred to artificially inseminated recipients. Of those 9 twin pregnancies, three delivered male and female offsprings. The females had tufts of long coarse hair and short blind pouch at the vaginal end. At necropsy, hypoplastic testicles and epididymis, which connected to the uterus through the spermatic cord, were found and seminal vesicles were also noted. All females had mixed sex chromosome configuration (60, XX and 60, XY). These results suggest that the combined ET program can cause freemartinism, which reduces the efficiency of clone cattle production.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.63.577</identifier><identifier>PMID: 11411508</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>ANIMAL EMBRYOS ; Animals ; ARTIFICIAL INSEMINATION ; Birth Weight ; CATTLE ; CELLS ; EMBRYO TRANSFER ; Embryo Transfer - adverse effects ; Embryo Transfer - veterinary ; Female ; Fibroblasts - physiology ; FREEMARTINISM ; Freemartinism - etiology ; Freemartinism - genetics ; Freemartinism - pathology ; Insemination, Artificial - adverse effects ; Insemination, Artificial - veterinary ; Male ; Nuclear Transfer Techniques ; NUCLEUS ; Pregnancy ; REPRODUCTIVE DISORDERS ; somatic cell nuclear transfer ; Twins</subject><ispartof>Journal of Veterinary Medical Science, 2001, Vol.63(5), pp.577-578</ispartof><rights>2001 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c479t-b2835dc5f1bf0ab7e936e47a211fb66d111f2bae03435495070dfffe50ee19f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11411508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, W.S. (Seoul National Univ., Suwon (Korea R.))</creatorcontrib><creatorcontrib>Cho, J.K</creatorcontrib><creatorcontrib>Kim, K.Y</creatorcontrib><creatorcontrib>Shin, S.J</creatorcontrib><creatorcontrib>Kim, S.K</creatorcontrib><creatorcontrib>Park, J.I</creatorcontrib><creatorcontrib>Kim. D.Y</creatorcontrib><creatorcontrib>Lee, J.K</creatorcontrib><creatorcontrib>Lim, J.M</creatorcontrib><creatorcontrib>Lee, B.C</creatorcontrib><title>Births of freemartins derived from embryos reconstructed with ear fibroblasts</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Although the combination of artificial insemination (AI) and embryo transfer (ET) is effective for preventing large offspring syndrome in clone cattle production, it may cause freemartinism. In this study, 51 reconstructed embryos were transferred to artificially inseminated recipients. Of those 9 twin pregnancies, three delivered male and female offsprings. The females had tufts of long coarse hair and short blind pouch at the vaginal end. At necropsy, hypoplastic testicles and epididymis, which connected to the uterus through the spermatic cord, were found and seminal vesicles were also noted. All females had mixed sex chromosome configuration (60, XX and 60, XY). These results suggest that the combined ET program can cause freemartinism, which reduces the efficiency of clone cattle production.</description><subject>ANIMAL EMBRYOS</subject><subject>Animals</subject><subject>ARTIFICIAL INSEMINATION</subject><subject>Birth Weight</subject><subject>CATTLE</subject><subject>CELLS</subject><subject>EMBRYO TRANSFER</subject><subject>Embryo Transfer - adverse effects</subject><subject>Embryo Transfer - veterinary</subject><subject>Female</subject><subject>Fibroblasts - physiology</subject><subject>FREEMARTINISM</subject><subject>Freemartinism - etiology</subject><subject>Freemartinism - genetics</subject><subject>Freemartinism - pathology</subject><subject>Insemination, Artificial - adverse effects</subject><subject>Insemination, Artificial - veterinary</subject><subject>Male</subject><subject>Nuclear Transfer Techniques</subject><subject>NUCLEUS</subject><subject>Pregnancy</subject><subject>REPRODUCTIVE DISORDERS</subject><subject>somatic cell nuclear transfer</subject><subject>Twins</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1rFTEUQINY7LO6cq0MCG5knvmaZLJTix8tLbroPiQzN33zmJnU3Eyl_9485tGCmwRyD4fkhJA3jG4ZN_zT_n7CrRLbRutnZMOE1LWWwjwnG2qYqjVv6Cl5ibinlDOpzAtyyphkrKHthlx_HVLeYRVDFRLA5FIeZqx6SMM99OUsThVMPj1ErBJ0ccacli6X0d8h7ypwqQqDT9GPDjO-IifBjQivj_sZufn-7eb8Z33168fF-ZerupPa5NrzVjR91wTmA3VegxEKpHacseCV6lnZuXdAhRSNNA3VtA8hQEMBmAnijHxYtXcp_lkAs50G7GAc3QxxQavLw7U0bQHf_wfu45LmcjVbSrSqlZQfqI8r1aWImCDYuzSUEg-WUXtIbA-JrRK2JC70u6Nz8RP0T-yxaQE-r8Aes7uFR-CQthvhSbYuxfk46nYuWZiL4u2qCC5ad5sGtJe_efk_SqnWSvwDg5WYTQ</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>Hwang, W.S. 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| ispartof | Journal of Veterinary Medical Science, 2001, Vol.63(5), pp.577-578 |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | ANIMAL EMBRYOS Animals ARTIFICIAL INSEMINATION Birth Weight CATTLE CELLS EMBRYO TRANSFER Embryo Transfer - adverse effects Embryo Transfer - veterinary Female Fibroblasts - physiology FREEMARTINISM Freemartinism - etiology Freemartinism - genetics Freemartinism - pathology Insemination, Artificial - adverse effects Insemination, Artificial - veterinary Male Nuclear Transfer Techniques NUCLEUS Pregnancy REPRODUCTIVE DISORDERS somatic cell nuclear transfer Twins |
| title | Births of freemartins derived from embryos reconstructed with ear fibroblasts |
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