Human somatostatin receptor subtypes in acromegaly : Distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes

Recently, studies using somatostatin (SRIF) analogs preferential for either the SRIF receptor 2 (SSTR2) or the SSTR5 subtype demonstrated a variable suppression of GH and PRL release from GH-secreting human adenomas. These data suggested the concept of SSTR subtype specificity in such tumors. In the...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2000-02, Vol.85 (2), p.781-792
Hauptverfasser:	JAQUET, P, SAVEANU, A, GUNZ, G, FINA, F, ZAMORA, A. J, GRINO, M, CULLER, M. D, MOREAU, J. P, ENJALBERT, A, OUAFIK, L. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly - metabolism Adenoma - metabolism Adult Biological and medical sciences Cells, Cultured Drug Combinations Endocrinopathies Female Hormones - pharmacology Human Growth Hormone - antagonists & inhibitors Human Growth Hormone - secretion Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Octreotide - pharmacology Oligopeptides - pharmacology Phenotype Piperazines - pharmacology Prolactin - antagonists & inhibitors Receptors, Somatostatin - agonists Receptors, Somatostatin - genetics Receptors, Somatotropin - genetics RNA, Messenger - metabolism Somatostatin - analogs & derivatives Somatostatin - pharmacology
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