A prospective evaluation of new rapid urease tests before and after eradication treatment of Helicobacter pylori, in comparison with histology, culture and 13C-urea breath test
Background: The rapid urease test is a simple and cost-effective method to detect Helicobacter pylori in biopsy specimens. The aim of this study was to evaluate the accuracy of two new rapid urease tests, Helicocheck and PyloriTek, before and after eradication. Methods: A total of 278 patients, in...
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| Veröffentlicht in: | Gastrointestinal endoscopy 2000-02, Vol.51 (2), p.164-168 |
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| creator | Nishikawa, Keiko Sugiyama, Toshiro Kato, Mototsugu Ishizuka, Jun Kagaya, Hidetoshi Hokari, Kaku Asaka, Masahiro |
| description | Background: The rapid urease test is a simple and cost-effective method to detect
Helicobacter pylori in biopsy specimens. The aim of this study was to evaluate the accuracy of two new rapid urease tests, Helicocheck and PyloriTek, before and after eradication.
Methods: A total of 278 patients, including 115 patients who had not undergone eradication of
H pylori and 163 patients after eradication treatment, were enrolled. Eight biopsy specimens were taken from both the antrum and the body of the stomach for histology, culture, and two rapid urease tests. Assessment of
H pylori infection was determined by the combination of histology, culture, and
13C-urea breath test.
Results: Overall sensitivity, specificity, and positive and negative predictive values of the Helicocheck before eradication were 91.0%, 100%, 100%, and 62.5%; PyloriTek, 92.0%, 100%, 100%, and 65.2%. Those of Helicocheck after eradication were, respectively, 60.5%, 99.2%, 95.8%, and 89.2%; PyloriTek, 60.5%, 99.2%, 95.8%, and 89.2%. For the Helicocheck, determination of the infection status of
H pylori by biopsies from the gastric body had a significantly higher sensitivity than antral biopsies. After eradication, the combination of 1 antral biopsy and 1 biopsy from the body was not effective enough to improve the overall sensitivity.
Conclusions: Helicocheck and PyloriTek have equally satisfactory overall sensitivity before eradication treatment. However, the sensitivity of these rapid urease tests was lower after eradication than before eradication. (Gastrointest Endosc 2000;51:164-8.) |
| doi_str_mv | 10.1016/S0016-5107(00)70412-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70915936</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0016510700704123</els_id><sourcerecordid>70915936</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2378-41f131489d7c5e3014e1d447c9bbc641150d32f39aa0e6f66858fb33223d4d493</originalsourceid><addsrcrecordid>eNqFkUFv1DAUhCMEokvhJ4B8QAikBp5jJ05OVbUCilSJA3C2HPuZNcrGwXa22n_FT8TZrIAbF7_LNzPWTFE8p_CWAm3efYH8ljUF8RrgjQBOq5I9KDYUOlE2QnQPi80f5KJ4EuMPAGgrRh8XFxSaGqq63RS_bsgUfJxQJ3dAggc1zCo5PxJvyYj3JKjJGTIHVBFJwpgi6dH6gESNhiibMBAMyji9ylIm0x7HtBjc4uC075VeqOk4-OCuiBuJ9vtJBRczf-_SjuxcTH7w349XRM9Dms_ulG3LJZn0i-nuFP-0eGTVEPHZ-V4W3z68_7q9Le8-f_y0vbkrdcVEW3JqKaO87YzQNTKgHKnhXOiu73XDKa3BsMqyTinAxjZNW7e2Z6yqmOGGd-yyeLX65np-zjlY7l3UOAxqRD9HKaCjdceaDNYrqHOPMaCVU3B7FY6Sglymkqep5LKDBJCnqSTLuhfngLnfo_lHtW6TgZdnQEWtBhvUqF38y1WCcU4zdr1imNs4OAwyaoejRuNCXlUa7_7zk99GaLJI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70915936</pqid></control><display><type>article</type><title>A prospective evaluation of new rapid urease tests before and after eradication treatment of Helicobacter pylori, in comparison with histology, culture and 13C-urea breath test</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Nishikawa, Keiko ; Sugiyama, Toshiro ; Kato, Mototsugu ; Ishizuka, Jun ; Kagaya, Hidetoshi ; Hokari, Kaku ; Asaka, Masahiro</creator><creatorcontrib>Nishikawa, Keiko ; Sugiyama, Toshiro ; Kato, Mototsugu ; Ishizuka, Jun ; Kagaya, Hidetoshi ; Hokari, Kaku ; Asaka, Masahiro</creatorcontrib><description>Background: The rapid urease test is a simple and cost-effective method to detect
Helicobacter pylori in biopsy specimens. The aim of this study was to evaluate the accuracy of two new rapid urease tests, Helicocheck and PyloriTek, before and after eradication.
Methods: A total of 278 patients, including 115 patients who had not undergone eradication of
H pylori and 163 patients after eradication treatment, were enrolled. Eight biopsy specimens were taken from both the antrum and the body of the stomach for histology, culture, and two rapid urease tests. Assessment of
H pylori infection was determined by the combination of histology, culture, and
13C-urea breath test.
Results: Overall sensitivity, specificity, and positive and negative predictive values of the Helicocheck before eradication were 91.0%, 100%, 100%, and 62.5%; PyloriTek, 92.0%, 100%, 100%, and 65.2%. Those of Helicocheck after eradication were, respectively, 60.5%, 99.2%, 95.8%, and 89.2%; PyloriTek, 60.5%, 99.2%, 95.8%, and 89.2%. For the Helicocheck, determination of the infection status of
H pylori by biopsies from the gastric body had a significantly higher sensitivity than antral biopsies. After eradication, the combination of 1 antral biopsy and 1 biopsy from the body was not effective enough to improve the overall sensitivity.
Conclusions: Helicocheck and PyloriTek have equally satisfactory overall sensitivity before eradication treatment. However, the sensitivity of these rapid urease tests was lower after eradication than before eradication. (Gastrointest Endosc 2000;51:164-8.)</description><identifier>ISSN: 0016-5107</identifier><identifier>EISSN: 1097-6779</identifier><identifier>DOI: 10.1016/S0016-5107(00)70412-3</identifier><identifier>PMID: 10650258</identifier><identifier>CODEN: GAENBQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Biological and medical sciences ; Biopsy ; Breath Tests ; Carbon Isotopes ; Digestive system ; Female ; Gastric Mucosa - chemistry ; Gastric Mucosa - pathology ; Gastritis - microbiology ; Helicobacter Infections - complications ; Helicobacter Infections - diagnosis ; Helicobacter Infections - drug therapy ; Helicobacter Infections - pathology ; Helicobacter pylori - isolation & purification ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Peptic Ulcer - microbiology ; Predictive Value of Tests ; Pyloric Antrum - chemistry ; Pyloric Antrum - pathology ; Reagent Kits, Diagnostic ; Sensitivity and Specificity ; Urea - analysis ; Urease - analysis</subject><ispartof>Gastrointestinal endoscopy, 2000-02, Vol.51 (2), p.164-168</ispartof><rights>2000 American Society for Gastrointestinal Endoscopy</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2378-41f131489d7c5e3014e1d447c9bbc641150d32f39aa0e6f66858fb33223d4d493</citedby><cites>FETCH-LOGICAL-c2378-41f131489d7c5e3014e1d447c9bbc641150d32f39aa0e6f66858fb33223d4d493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0016-5107(00)70412-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1273441$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10650258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishikawa, Keiko</creatorcontrib><creatorcontrib>Sugiyama, Toshiro</creatorcontrib><creatorcontrib>Kato, Mototsugu</creatorcontrib><creatorcontrib>Ishizuka, Jun</creatorcontrib><creatorcontrib>Kagaya, Hidetoshi</creatorcontrib><creatorcontrib>Hokari, Kaku</creatorcontrib><creatorcontrib>Asaka, Masahiro</creatorcontrib><title>A prospective evaluation of new rapid urease tests before and after eradication treatment of Helicobacter pylori, in comparison with histology, culture and 13C-urea breath test</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Background: The rapid urease test is a simple and cost-effective method to detect
Helicobacter pylori in biopsy specimens. The aim of this study was to evaluate the accuracy of two new rapid urease tests, Helicocheck and PyloriTek, before and after eradication.
Methods: A total of 278 patients, including 115 patients who had not undergone eradication of
H pylori and 163 patients after eradication treatment, were enrolled. Eight biopsy specimens were taken from both the antrum and the body of the stomach for histology, culture, and two rapid urease tests. Assessment of
H pylori infection was determined by the combination of histology, culture, and
13C-urea breath test.
Results: Overall sensitivity, specificity, and positive and negative predictive values of the Helicocheck before eradication were 91.0%, 100%, 100%, and 62.5%; PyloriTek, 92.0%, 100%, 100%, and 65.2%. Those of Helicocheck after eradication were, respectively, 60.5%, 99.2%, 95.8%, and 89.2%; PyloriTek, 60.5%, 99.2%, 95.8%, and 89.2%. For the Helicocheck, determination of the infection status of
H pylori by biopsies from the gastric body had a significantly higher sensitivity than antral biopsies. After eradication, the combination of 1 antral biopsy and 1 biopsy from the body was not effective enough to improve the overall sensitivity.
Conclusions: Helicocheck and PyloriTek have equally satisfactory overall sensitivity before eradication treatment. However, the sensitivity of these rapid urease tests was lower after eradication than before eradication. (Gastrointest Endosc 2000;51:164-8.)</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Breath Tests</subject><subject>Carbon Isotopes</subject><subject>Digestive system</subject><subject>Female</subject><subject>Gastric Mucosa - chemistry</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastritis - microbiology</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Peptic Ulcer - microbiology</subject><subject>Predictive Value of Tests</subject><subject>Pyloric Antrum - chemistry</subject><subject>Pyloric Antrum - pathology</subject><subject>Reagent Kits, Diagnostic</subject><subject>Sensitivity and Specificity</subject><subject>Urea - analysis</subject><subject>Urease - analysis</subject><issn>0016-5107</issn><issn>1097-6779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAUhCMEokvhJ4B8QAikBp5jJ05OVbUCilSJA3C2HPuZNcrGwXa22n_FT8TZrIAbF7_LNzPWTFE8p_CWAm3efYH8ljUF8RrgjQBOq5I9KDYUOlE2QnQPi80f5KJ4EuMPAGgrRh8XFxSaGqq63RS_bsgUfJxQJ3dAggc1zCo5PxJvyYj3JKjJGTIHVBFJwpgi6dH6gESNhiibMBAMyji9ylIm0x7HtBjc4uC075VeqOk4-OCuiBuJ9vtJBRczf-_SjuxcTH7w349XRM9Dms_ulG3LJZn0i-nuFP-0eGTVEPHZ-V4W3z68_7q9Le8-f_y0vbkrdcVEW3JqKaO87YzQNTKgHKnhXOiu73XDKa3BsMqyTinAxjZNW7e2Z6yqmOGGd-yyeLX65np-zjlY7l3UOAxqRD9HKaCjdceaDNYrqHOPMaCVU3B7FY6Sglymkqep5LKDBJCnqSTLuhfngLnfo_lHtW6TgZdnQEWtBhvUqF38y1WCcU4zdr1imNs4OAwyaoejRuNCXlUa7_7zk99GaLJI</recordid><startdate>200002</startdate><enddate>200002</enddate><creator>Nishikawa, Keiko</creator><creator>Sugiyama, Toshiro</creator><creator>Kato, Mototsugu</creator><creator>Ishizuka, Jun</creator><creator>Kagaya, Hidetoshi</creator><creator>Hokari, Kaku</creator><creator>Asaka, Masahiro</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200002</creationdate><title>A prospective evaluation of new rapid urease tests before and after eradication treatment of Helicobacter pylori, in comparison with histology, culture and 13C-urea breath test</title><author>Nishikawa, Keiko ; Sugiyama, Toshiro ; Kato, Mototsugu ; Ishizuka, Jun ; Kagaya, Hidetoshi ; Hokari, Kaku ; Asaka, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2378-41f131489d7c5e3014e1d447c9bbc641150d32f39aa0e6f66858fb33223d4d493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Breath Tests</topic><topic>Carbon Isotopes</topic><topic>Digestive system</topic><topic>Female</topic><topic>Gastric Mucosa - chemistry</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastritis - microbiology</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - diagnosis</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter Infections - pathology</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Peptic Ulcer - microbiology</topic><topic>Predictive Value of Tests</topic><topic>Pyloric Antrum - chemistry</topic><topic>Pyloric Antrum - pathology</topic><topic>Reagent Kits, Diagnostic</topic><topic>Sensitivity and Specificity</topic><topic>Urea - analysis</topic><topic>Urease - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishikawa, Keiko</creatorcontrib><creatorcontrib>Sugiyama, Toshiro</creatorcontrib><creatorcontrib>Kato, Mototsugu</creatorcontrib><creatorcontrib>Ishizuka, Jun</creatorcontrib><creatorcontrib>Kagaya, Hidetoshi</creatorcontrib><creatorcontrib>Hokari, Kaku</creatorcontrib><creatorcontrib>Asaka, Masahiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishikawa, Keiko</au><au>Sugiyama, Toshiro</au><au>Kato, Mototsugu</au><au>Ishizuka, Jun</au><au>Kagaya, Hidetoshi</au><au>Hokari, Kaku</au><au>Asaka, Masahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective evaluation of new rapid urease tests before and after eradication treatment of Helicobacter pylori, in comparison with histology, culture and 13C-urea breath test</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>2000-02</date><risdate>2000</risdate><volume>51</volume><issue>2</issue><spage>164</spage><epage>168</epage><pages>164-168</pages><issn>0016-5107</issn><eissn>1097-6779</eissn><coden>GAENBQ</coden><abstract>Background: The rapid urease test is a simple and cost-effective method to detect
Helicobacter pylori in biopsy specimens. The aim of this study was to evaluate the accuracy of two new rapid urease tests, Helicocheck and PyloriTek, before and after eradication.
Methods: A total of 278 patients, including 115 patients who had not undergone eradication of
H pylori and 163 patients after eradication treatment, were enrolled. Eight biopsy specimens were taken from both the antrum and the body of the stomach for histology, culture, and two rapid urease tests. Assessment of
H pylori infection was determined by the combination of histology, culture, and
13C-urea breath test.
Results: Overall sensitivity, specificity, and positive and negative predictive values of the Helicocheck before eradication were 91.0%, 100%, 100%, and 62.5%; PyloriTek, 92.0%, 100%, 100%, and 65.2%. Those of Helicocheck after eradication were, respectively, 60.5%, 99.2%, 95.8%, and 89.2%; PyloriTek, 60.5%, 99.2%, 95.8%, and 89.2%. For the Helicocheck, determination of the infection status of
H pylori by biopsies from the gastric body had a significantly higher sensitivity than antral biopsies. After eradication, the combination of 1 antral biopsy and 1 biopsy from the body was not effective enough to improve the overall sensitivity.
Conclusions: Helicocheck and PyloriTek have equally satisfactory overall sensitivity before eradication treatment. However, the sensitivity of these rapid urease tests was lower after eradication than before eradication. (Gastrointest Endosc 2000;51:164-8.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>10650258</pmid><doi>10.1016/S0016-5107(00)70412-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | Gastrointestinal endoscopy, 2000-02, Vol.51 (2), p.164-168 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Biopsy Breath Tests Carbon Isotopes Digestive system Female Gastric Mucosa - chemistry Gastric Mucosa - pathology Gastritis - microbiology Helicobacter Infections - complications Helicobacter Infections - diagnosis Helicobacter Infections - drug therapy Helicobacter Infections - pathology Helicobacter pylori - isolation & purification Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peptic Ulcer - microbiology Predictive Value of Tests Pyloric Antrum - chemistry Pyloric Antrum - pathology Reagent Kits, Diagnostic Sensitivity and Specificity Urea - analysis Urease - analysis |
| title | A prospective evaluation of new rapid urease tests before and after eradication treatment of Helicobacter pylori, in comparison with histology, culture and 13C-urea breath test |
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