Polymorphism of HLA-A, -B, -DRB1, -DQA1 and -DQB1 haplotypes in a Croatian population
We describe for the first time extended haplotypes in a Croatian population. The present study gives the HLA‐A, ‐B, ‐DRB1, ‐DQA1 and ‐DQB1 allele and haplotype frequencies in 105 families with at least two offspring. All individuals were studied by conventional serology for HLA class I antigens (A a...
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| Veröffentlicht in: | European journal of immunogenetics 2000-02, Vol.27 (1), p.47-51 |
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| container_title | European journal of immunogenetics |
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| creator | Grubic, Z. Zunec, R. Cec uk-Jelic ic, E. Kerhin-Brkljacic, V. Kastelan, A. |
| description | We describe for the first time extended haplotypes in a Croatian population. The present study gives the HLA‐A, ‐B, ‐DRB1, ‐DQA1 and ‐DQB1 allele and haplotype frequencies in 105 families with at least two offspring. All individuals were studied by conventional serology for HLA class I antigens (A and B), while class II alleles (DRB1, DQA1, DQB1) were typed using the PCR–SSOP method. HLA genotyping was performed by segregation in all 105 families. For extended haplotype analysis, 420 independent parental haplotypes were included. Fourteen HLA‐A, 18 HLA‐B, 28 DRB1, 9 DQA1 and 11 DQB1 alleles were found in the studied population. Most of the DRB1 alleles in our population had an exclusive association with one specific DQA1‐DQB1 combination. This strong linkage disequilibrium within the HLA class II region is often extended to the HLA‐B locus. A total of 10 HLA‐A, ‐B, ‐DRB1, ‐DQA1, ‐DQB1 haplotypes were observed with a frequency ≤ 1.0%. The three most frequent haplotypes were HLA‐A1, B8, DRB1*0301, DQA1*0501, DQB1*0201; HLA‐A3, B7, DRB1*1501, DQA1*0102, DQB1*0602 and HLA‐A24, B44, DRB1*0701, DQA1*0201, DQB1*02. These results should provide a useful reference for further anthropological studies, transplantation studies, and studies of associations between HLA and diseases. |
| doi_str_mv | 10.1046/j.1365-2370.2000.00193.x |
| format | Article |
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The present study gives the HLA‐A, ‐B, ‐DRB1, ‐DQA1 and ‐DQB1 allele and haplotype frequencies in 105 families with at least two offspring. All individuals were studied by conventional serology for HLA class I antigens (A and B), while class II alleles (DRB1, DQA1, DQB1) were typed using the PCR–SSOP method. HLA genotyping was performed by segregation in all 105 families. For extended haplotype analysis, 420 independent parental haplotypes were included. Fourteen HLA‐A, 18 HLA‐B, 28 DRB1, 9 DQA1 and 11 DQB1 alleles were found in the studied population. Most of the DRB1 alleles in our population had an exclusive association with one specific DQA1‐DQB1 combination. This strong linkage disequilibrium within the HLA class II region is often extended to the HLA‐B locus. A total of 10 HLA‐A, ‐B, ‐DRB1, ‐DQA1, ‐DQB1 haplotypes were observed with a frequency ≤ 1.0%. The three most frequent haplotypes were HLA‐A1, B8, DRB1*0301, DQA1*0501, DQB1*0201; HLA‐A3, B7, DRB1*1501, DQA1*0102, DQB1*0602 and HLA‐A24, B44, DRB1*0701, DQA1*0201, DQB1*02. These results should provide a useful reference for further anthropological studies, transplantation studies, and studies of associations between HLA and diseases.</description><identifier>ISSN: 0960-7420</identifier><identifier>EISSN: 1365-2370</identifier><identifier>DOI: 10.1046/j.1365-2370.2000.00193.x</identifier><identifier>PMID: 10651851</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Croatia ; Genetics, Population ; Haplotypes ; histocompatibility locus HLA ; HLA-A Antigens - genetics ; HLA-B Antigens - genetics ; HLA-DQ alpha-Chains ; HLA-DQ Antigens - genetics ; HLA-DQ beta-Chains ; HLA-DR Antigens - genetics ; HLA-DRB1 Chains ; Humans ; Linkage Disequilibrium ; Nucleic Acid Hybridization ; Polymorphism, Genetic</subject><ispartof>European journal of immunogenetics, 2000-02, Vol.27 (1), p.47-51</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4333-3920381607d7cf2f14cb92f5237c723c243b74750bffef013120bc4dbcb559923</citedby><cites>FETCH-LOGICAL-c4333-3920381607d7cf2f14cb92f5237c723c243b74750bffef013120bc4dbcb559923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2370.2000.00193.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2370.2000.00193.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10651851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grubic, Z.</creatorcontrib><creatorcontrib>Zunec, R.</creatorcontrib><creatorcontrib>Cec uk-Jelic ic, E.</creatorcontrib><creatorcontrib>Kerhin-Brkljacic, V.</creatorcontrib><creatorcontrib>Kastelan, A.</creatorcontrib><title>Polymorphism of HLA-A, -B, -DRB1, -DQA1 and -DQB1 haplotypes in a Croatian population</title><title>European journal of immunogenetics</title><addtitle>Eur J Immunogenet</addtitle><description>We describe for the first time extended haplotypes in a Croatian population. The present study gives the HLA‐A, ‐B, ‐DRB1, ‐DQA1 and ‐DQB1 allele and haplotype frequencies in 105 families with at least two offspring. All individuals were studied by conventional serology for HLA class I antigens (A and B), while class II alleles (DRB1, DQA1, DQB1) were typed using the PCR–SSOP method. HLA genotyping was performed by segregation in all 105 families. For extended haplotype analysis, 420 independent parental haplotypes were included. Fourteen HLA‐A, 18 HLA‐B, 28 DRB1, 9 DQA1 and 11 DQB1 alleles were found in the studied population. Most of the DRB1 alleles in our population had an exclusive association with one specific DQA1‐DQB1 combination. This strong linkage disequilibrium within the HLA class II region is often extended to the HLA‐B locus. A total of 10 HLA‐A, ‐B, ‐DRB1, ‐DQA1, ‐DQB1 haplotypes were observed with a frequency ≤ 1.0%. The three most frequent haplotypes were HLA‐A1, B8, DRB1*0301, DQA1*0501, DQB1*0201; HLA‐A3, B7, DRB1*1501, DQA1*0102, DQB1*0602 and HLA‐A24, B44, DRB1*0701, DQA1*0201, DQB1*02. These results should provide a useful reference for further anthropological studies, transplantation studies, and studies of associations between HLA and diseases.</description><subject>Croatia</subject><subject>Genetics, Population</subject><subject>Haplotypes</subject><subject>histocompatibility locus HLA</subject><subject>HLA-A Antigens - genetics</subject><subject>HLA-B Antigens - genetics</subject><subject>HLA-DQ alpha-Chains</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DQ beta-Chains</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DRB1 Chains</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Nucleic Acid Hybridization</subject><subject>Polymorphism, Genetic</subject><issn>0960-7420</issn><issn>1365-2370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtu2zAQRYmgReI8fiHgqqtKHZIiaQLd2E4aO3DzQoIsCYomEbmSqIg2av99pCoIumsXxAzAc2cGByFMICWQiW_rlDDBE8okpBQAUgCiWLo7QKOPj09oBEpAIjMKR-g4xnUHMaLEIToiIDgZczJCT3eh3FehbV6KWOHg8Xw5SSZfcTLt3sXDlPTlfkKwqVd9NyX4xTRl2OwbF3FRY4NnbTCbwtS4Cc227NpQn6LP3pTRnb3XE_T04_JxNk-Wt1eL2WSZ2IwxljBFgY2JALmS1lNPMpsr6nl3vpWUWZqxXGaSQ-698_31FHKbrXKbc64UZSfoyzC3acPr1sWNropoXVma2oVt1BIU4UL-GyQyU0qSHhwPoG1DjK3zummLyrR7TUD37vVa94p1r1j37vUf93rXRc_fd2zzyq3-Cg6yO-D7APwuSrf_78F6cb3omi6eDPEibtzuI27aX1pIJrl-vrnS148385-CcS3YG256m_s</recordid><startdate>200002</startdate><enddate>200002</enddate><creator>Grubic, Z.</creator><creator>Zunec, R.</creator><creator>Cec uk-Jelic ic, E.</creator><creator>Kerhin-Brkljacic, V.</creator><creator>Kastelan, A.</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200002</creationdate><title>Polymorphism of HLA-A, -B, -DRB1, -DQA1 and -DQB1 haplotypes in a Croatian population</title><author>Grubic, Z. ; Zunec, R. ; Cec uk-Jelic ic, E. ; Kerhin-Brkljacic, V. ; Kastelan, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4333-3920381607d7cf2f14cb92f5237c723c243b74750bffef013120bc4dbcb559923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Croatia</topic><topic>Genetics, Population</topic><topic>Haplotypes</topic><topic>histocompatibility locus HLA</topic><topic>HLA-A Antigens - genetics</topic><topic>HLA-B Antigens - genetics</topic><topic>HLA-DQ alpha-Chains</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DQ beta-Chains</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DRB1 Chains</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Nucleic Acid Hybridization</topic><topic>Polymorphism, Genetic</topic><toplevel>online_resources</toplevel><creatorcontrib>Grubic, Z.</creatorcontrib><creatorcontrib>Zunec, R.</creatorcontrib><creatorcontrib>Cec uk-Jelic ic, E.</creatorcontrib><creatorcontrib>Kerhin-Brkljacic, V.</creatorcontrib><creatorcontrib>Kastelan, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grubic, Z.</au><au>Zunec, R.</au><au>Cec uk-Jelic ic, E.</au><au>Kerhin-Brkljacic, V.</au><au>Kastelan, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphism of HLA-A, -B, -DRB1, -DQA1 and -DQB1 haplotypes in a Croatian population</atitle><jtitle>European journal of immunogenetics</jtitle><addtitle>Eur J Immunogenet</addtitle><date>2000-02</date><risdate>2000</risdate><volume>27</volume><issue>1</issue><spage>47</spage><epage>51</epage><pages>47-51</pages><issn>0960-7420</issn><eissn>1365-2370</eissn><abstract>We describe for the first time extended haplotypes in a Croatian population. The present study gives the HLA‐A, ‐B, ‐DRB1, ‐DQA1 and ‐DQB1 allele and haplotype frequencies in 105 families with at least two offspring. All individuals were studied by conventional serology for HLA class I antigens (A and B), while class II alleles (DRB1, DQA1, DQB1) were typed using the PCR–SSOP method. HLA genotyping was performed by segregation in all 105 families. For extended haplotype analysis, 420 independent parental haplotypes were included. Fourteen HLA‐A, 18 HLA‐B, 28 DRB1, 9 DQA1 and 11 DQB1 alleles were found in the studied population. Most of the DRB1 alleles in our population had an exclusive association with one specific DQA1‐DQB1 combination. This strong linkage disequilibrium within the HLA class II region is often extended to the HLA‐B locus. A total of 10 HLA‐A, ‐B, ‐DRB1, ‐DQA1, ‐DQB1 haplotypes were observed with a frequency ≤ 1.0%. The three most frequent haplotypes were HLA‐A1, B8, DRB1*0301, DQA1*0501, DQB1*0201; HLA‐A3, B7, DRB1*1501, DQA1*0102, DQB1*0602 and HLA‐A24, B44, DRB1*0701, DQA1*0201, DQB1*02. These results should provide a useful reference for further anthropological studies, transplantation studies, and studies of associations between HLA and diseases.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>10651851</pmid><doi>10.1046/j.1365-2370.2000.00193.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Croatia Genetics, Population Haplotypes histocompatibility locus HLA HLA-A Antigens - genetics HLA-B Antigens - genetics HLA-DQ alpha-Chains HLA-DQ Antigens - genetics HLA-DQ beta-Chains HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Linkage Disequilibrium Nucleic Acid Hybridization Polymorphism, Genetic |
| title | Polymorphism of HLA-A, -B, -DRB1, -DQA1 and -DQB1 haplotypes in a Croatian population |
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