Tumor necrosis factor-α inhibits leptin production in subcutaneous and omental adipocytes from morbidly obese humans

This study was undertaken to examine the regulation of leptin production from human adipocytes by tumor necrosis factor-alpha (TNFalpha). Adipocytes were isolated from adipose tissue obtained during bariatric surgical procedures (17 women and 3 men; body mass index, 52.5 +/- 2.4 kg/m2; age, 40 +/- 3...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2000-02, Vol.85 (2), p.530-535
Hauptverfasser:	FAWCETT, R. L, WAECHTER, A. S, WILLIAMS, L. B, PEILI ZHANG, LOUIE, R, JONES, R, INMAN, M, HUSE, J, CONSIDINE, R. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Adult Biological and medical sciences Cells, Cultured Dexamethasone - pharmacology Drug Combinations Female Glucocorticoids - pharmacology Humans Leptin - antagonists & inhibitors Leptin - biosynthesis Male Medical sciences Metabolic diseases Obesity Obesity, Morbid - metabolism Obesity, Morbid - pathology Omentum Skin Time Factors Tumor Necrosis Factor-alpha - pharmacology
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