Motor unit properties of nerve-intact extensor digitorum longus muscle grafts in young and old rats
Impaired reinnervation has been implicated as the cause of the threefold disparity in the recovery of maximum force (P0) of standard muscle grafts in old compared with young rats. The specific, null hypothesis of this study is that compared with age-matched control extensor digitorum longus (EDL) mu...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2001-06, Vol.56 (6), p.B254-B258 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Cederna, P S Asato, H Gu, X van der Meulen, J Kuzon, Jr, W M Carlson, B M Faulkner, J A |
| description | Impaired reinnervation has been implicated as the cause of the threefold disparity in the recovery of maximum force (P0) of standard muscle grafts in old compared with young rats. The specific, null hypothesis of this study is that compared with age-matched control extensor digitorum longus (EDL) muscles, nerve-intact EDL muscle grafts in young and old rats show no evidence of an age-related impairment in reinnervation. Nerve-intact grafts were performed in 3-month-old and 23-month-old rats and were evaluated 60 days postoperatively. Compared with age-matched control EDL muscles, nerve-intact grafts in young and old rats showed no difference in muscle mass or motor unit numbers. The mean motor unit P0 for nerve-intact graft muscles in both age groups was significantly lower than that of age-matched control muscles. These data support our hypothesis that if axons are allowed to regenerate in an endoneurial environment, there is no evidence of an age-related impairment in muscle reinnervation. |
| doi_str_mv | 10.1093/gerona/56.6.B254 |
| format | Article |
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The specific, null hypothesis of this study is that compared with age-matched control extensor digitorum longus (EDL) muscles, nerve-intact EDL muscle grafts in young and old rats show no evidence of an age-related impairment in reinnervation. Nerve-intact grafts were performed in 3-month-old and 23-month-old rats and were evaluated 60 days postoperatively. Compared with age-matched control EDL muscles, nerve-intact grafts in young and old rats showed no difference in muscle mass or motor unit numbers. The mean motor unit P0 for nerve-intact graft muscles in both age groups was significantly lower than that of age-matched control muscles. These data support our hypothesis that if axons are allowed to regenerate in an endoneurial environment, there is no evidence of an age-related impairment in muscle reinnervation.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/56.6.B254</identifier><identifier>PMID: 11382787</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Age ; Aging - physiology ; Animals ; Hindlimb ; Male ; Motor ability ; Motor Neurons - physiology ; Muscle Contraction ; Muscle, Skeletal - innervation ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiopathology ; Muscle, Skeletal - transplantation ; Muscular system ; Nerve Regeneration - physiology ; Rats ; Rats, Inbred Strains ; Reference Values ; Rodents ; Toes</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2001-06, Vol.56 (6), p.B254-B258</ispartof><rights>Copyright Gerontological Society of America, Incorporated Jun 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-52067b7f5cbcb287c5e3c756afe9dc1a18e4187349ee6a05d74d66a13c2b60b53</citedby><cites>FETCH-LOGICAL-c364t-52067b7f5cbcb287c5e3c756afe9dc1a18e4187349ee6a05d74d66a13c2b60b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11382787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cederna, P S</creatorcontrib><creatorcontrib>Asato, H</creatorcontrib><creatorcontrib>Gu, X</creatorcontrib><creatorcontrib>van der Meulen, J</creatorcontrib><creatorcontrib>Kuzon, Jr, W M</creatorcontrib><creatorcontrib>Carlson, B M</creatorcontrib><creatorcontrib>Faulkner, J A</creatorcontrib><title>Motor unit properties of nerve-intact extensor digitorum longus muscle grafts in young and old rats</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Impaired reinnervation has been implicated as the cause of the threefold disparity in the recovery of maximum force (P0) of standard muscle grafts in old compared with young rats. The specific, null hypothesis of this study is that compared with age-matched control extensor digitorum longus (EDL) muscles, nerve-intact EDL muscle grafts in young and old rats show no evidence of an age-related impairment in reinnervation. Nerve-intact grafts were performed in 3-month-old and 23-month-old rats and were evaluated 60 days postoperatively. Compared with age-matched control EDL muscles, nerve-intact grafts in young and old rats showed no difference in muscle mass or motor unit numbers. The mean motor unit P0 for nerve-intact graft muscles in both age groups was significantly lower than that of age-matched control muscles. These data support our hypothesis that if axons are allowed to regenerate in an endoneurial environment, there is no evidence of an age-related impairment in muscle reinnervation.</description><subject>Age</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Hindlimb</subject><subject>Male</subject><subject>Motor ability</subject><subject>Motor Neurons - physiology</subject><subject>Muscle Contraction</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscle, Skeletal - transplantation</subject><subject>Muscular system</subject><subject>Nerve Regeneration - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reference Values</subject><subject>Rodents</subject><subject>Toes</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1LxDAQhoMorq7ePUnw4K1r0jRJe9TFL1C8KHgLaTotXdpkzYe4_94uuyA4l5nD8w4zD0IXlCwoqdhNB95ZfcPFQizucl4coBMqeZlxxj8Pp5nIKuOEiBk6DWFFtsXzYzSjlJW5LOUJMq8uOo-T7SNee7cGH3sI2LXYgv-GrLdRm4jhJ4INE9j0XT8F0ogHZ7sU8JiCGQB3Xrcx4N7ijUu2w9o22A0N9jqGM3TU6iHA-b7P0cfD_fvyKXt5e3xe3r5khokiZjwnQtay5aY2dV5Kw4EZyYVuoWoM1bSEgpaSFRWA0IQ3smiE0JSZvBak5myOrnd7p0e-EoSoxj4YGAZtwaWgJKloQaScwKt_4Molb6fbVE5KkTNasgkiO8h4F4KHVq19P2q_UZSorX21s6-4UEJt7U-Ry_3eVI_Q_AX2utkvzLGDOg</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Cederna, P S</creator><creator>Asato, H</creator><creator>Gu, X</creator><creator>van der Meulen, J</creator><creator>Kuzon, Jr, W M</creator><creator>Carlson, B M</creator><creator>Faulkner, J A</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Motor unit properties of nerve-intact extensor digitorum longus muscle grafts in young and old rats</title><author>Cederna, P S ; Asato, H ; Gu, X ; van der Meulen, J ; Kuzon, Jr, W M ; Carlson, B M ; Faulkner, J A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-52067b7f5cbcb287c5e3c756afe9dc1a18e4187349ee6a05d74d66a13c2b60b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Hindlimb</topic><topic>Male</topic><topic>Motor ability</topic><topic>Motor Neurons - physiology</topic><topic>Muscle Contraction</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscle, Skeletal - transplantation</topic><topic>Muscular system</topic><topic>Nerve Regeneration - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reference Values</topic><topic>Rodents</topic><topic>Toes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cederna, P S</creatorcontrib><creatorcontrib>Asato, H</creatorcontrib><creatorcontrib>Gu, X</creatorcontrib><creatorcontrib>van der Meulen, J</creatorcontrib><creatorcontrib>Kuzon, Jr, W M</creatorcontrib><creatorcontrib>Carlson, B M</creatorcontrib><creatorcontrib>Faulkner, J A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cederna, P S</au><au>Asato, H</au><au>Gu, X</au><au>van der Meulen, J</au><au>Kuzon, Jr, W M</au><au>Carlson, B M</au><au>Faulkner, J A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Motor unit properties of nerve-intact extensor digitorum longus muscle grafts in young and old rats</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>56</volume><issue>6</issue><spage>B254</spage><epage>B258</epage><pages>B254-B258</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Impaired reinnervation has been implicated as the cause of the threefold disparity in the recovery of maximum force (P0) of standard muscle grafts in old compared with young rats. The specific, null hypothesis of this study is that compared with age-matched control extensor digitorum longus (EDL) muscles, nerve-intact EDL muscle grafts in young and old rats show no evidence of an age-related impairment in reinnervation. Nerve-intact grafts were performed in 3-month-old and 23-month-old rats and were evaluated 60 days postoperatively. Compared with age-matched control EDL muscles, nerve-intact grafts in young and old rats showed no difference in muscle mass or motor unit numbers. The mean motor unit P0 for nerve-intact graft muscles in both age groups was significantly lower than that of age-matched control muscles. These data support our hypothesis that if axons are allowed to regenerate in an endoneurial environment, there is no evidence of an age-related impairment in muscle reinnervation.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>11382787</pmid><doi>10.1093/gerona/56.6.B254</doi><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Age Aging - physiology Animals Hindlimb Male Motor ability Motor Neurons - physiology Muscle Contraction Muscle, Skeletal - innervation Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Muscle, Skeletal - transplantation Muscular system Nerve Regeneration - physiology Rats Rats, Inbred Strains Reference Values Rodents Toes |
| title | Motor unit properties of nerve-intact extensor digitorum longus muscle grafts in young and old rats |
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