Gabapentin-lactam, a close analogue of the anticonvulsant gabapentin, exerts convulsant activity in amygdala kindled rats

The cyclic GABA analogue gabapentin (GBP), which recently has been marketed for treatment of epilepsy, is particularly effective against complex-partial seizures as occurring in temporal lobe epilepsy. In the present study, we compared the effects of GBP and its lactam analogue (GBP-L) in the amygda...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2000-02, Vol.361 (2), p.200-205
Hauptverfasser:	Potschka, H, Feuerstein, T J, Löscher, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Amines Amygdala - drug effects Amygdala - physiology Animals Anticonvulsants - pharmacology Aza Compounds - pharmacology Convulsants - pharmacology Cyclohexanecarboxylic Acids Dose-Response Relationship, Drug Female Gabapentin gamma-Aminobutyric Acid Kindling, Neurologic - drug effects Rats Rats, Wistar Spiro Compounds - pharmacology
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