Maturation and Trafficking of Monocyte-Derived Dendritic Cells in Monkeys: Implications for Dendritic Cell-Based Vaccines

Human dendritic cells (DC) have polarized responses to chemokines as a function of maturation state, but the effect of maturation on DC trafficking in vivo is not known. We have addressed this question in a highly relevant rhesus macaque model. We demonstrate that immature and CD40 ligand-matured mo...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-03, Vol.164 (5), p.2487-2495
Hauptverfasser:	Barratt-Boyes, Simon M, Zimmer, Michael I, Harshyne, Larry A, Meyer, E. Michael, Watkins, Simon C, Capuano, Saverio, III, Murphey-Corb, Michael, Falo, Louis D., Jr, Donnenberg, Albert D
Format:	Artikel
Sprache:	eng
Schlagworte:	6Ckine Adoptive Transfer - methods Animals CCR5 protein CCR7 protein CD40 Antigens - metabolism CD40 Ligand Cell Count Cell Differentiation - immunology Cell Movement - immunology Cells, Cultured Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - transplantation Genetic Vectors - immunology Green Fluorescent Proteins Humans Immunophenotyping Injections, Intradermal Ligands Luminescent Proteins - administration & dosage Luminescent Proteins - genetics Luminescent Proteins - immunology Lymph Nodes - cytology Lymph Nodes - immunology Lymph Nodes - metabolism Macaca mulatta macrophage inflammatory protein 1^a Membrane Glycoproteins - pharmacology Monocytes - cytology Monocytes - immunology Pinocytosis - immunology Receptors, Chemokine - biosynthesis Skin - cytology Skin - immunology Transfection Vaccines - immunology
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