Distinct Immunity in Patients with Visceral Leishmaniasis from that in Subclinically Infected and Drug-Cured People: Implications for the Mechanism Underlying Drug Cure

Significant levels of IgG3 and IgG4 and high levels of IgG1 leishmania-specific antibody differentiated the immune states in 10 patients with visceral leishmaniasis from those of virtually all 20 drug-cured and 18 subclinically infected subjects, whereas the level of IgG2 antibody was nondiscriminat...

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Veröffentlicht in:	The Journal of infectious diseases 2001-07, Vol.184 (1), p.112-115
Hauptverfasser:	Hailu, Asrat, Menon, Juthika N., Berhe, Nega, Gedamu, Lashitew, Hassard, Thomas H., Kager, Petrus A., Olobo, Joseph, Bretscher, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies Antibodies, Protozoan - analysis Antigens Antimony Sodium Gluconate - therapeutic use Antiprotozoal Agents - therapeutic use Antiviral agents Biological and medical sciences Child Child, Preschool Concise Communications Enzyme-Linked Immunosorbent Assay Ethiopia Female Human viral diseases Humans Immunity Immunoglobulin G - analysis immunoglobulin G2 immunoglobulin G3 immunoglobulin G4 Infections Infectious diseases Leishmania Leishmaniasis, Visceral - drug therapy Leishmaniasis, Visceral - immunology Male Medical cures Medical research Medical sciences Middle Aged Parasites Pharmacology. Drug treatments Skin Tests Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Visceral leishmaniasis
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