The Alpha-fetoprotein Promoter Is the Target of Afr1-Mediated Postnatal Repression

The α-fetoprotein (AFP) gene is transcribed at high levels in the fetal liver and is repressed at birth, leading to low but detectable levels of AFP mRNA in the adult liver. This repression is regulated, in part, by a locus that is unlinked to AFP called Alpha-fetoprotein regulator 1 (Afr1). Previou...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2000-01, Vol.63 (2), p.173-180
Hauptverfasser:	Peyton, David K., Huang, Mei-Chuan, Giglia, Meredith A., Hughes, Nedda K., Spear, Brett T.
Format:	Artikel
Sprache:	eng
Schlagworte:	a-fetoprotein AFP gene Afr1 gene Alpha-fetoprotein regulator 1 protein alpha-Fetoproteins - genetics Animals Animals, Newborn Base Sequence Biological and medical sciences chromosome 15 Chromosome Mapping DNA Primers - genetics Enhancer Elements, Genetic Female Fetus - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Genes, Regulator Genes. Genome Humans Liver - metabolism Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Transgenic Molecular and cellular biology Molecular genetics Pregnancy Promoter Regions, Genetic RNA, Messenger - genetics RNA, Messenger - metabolism transgenes
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