Interleukin-6 Release by Cultured Peripheral Blood Mononuclear Cells Inversely Correlates with Height Velocity, Bone Age, Insulin-like Growth Factor-I, and Insulin-like Growth Factor Binding Protein-3 Serum Levels in Children with Perinatal HIV-1 Infection
Spontaneous and phytohemagglutinin (PHA)-stimulated interleukin (IL)-6 release by cultured peripheral blood mononuclear cells was related to height velocity, bone age, insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3) serum level standard deviation scores (SDS) of 32 children...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2000-03, Vol.94 (3), p.212-218 |
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| container_title | Clinical immunology (Orlando, Fla.) |
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| creator | de Martino, Maurizio Galli, Luisa Chiarelli, Francesco Verrotti, Alberto Rossi, Maria Elisabetta Bindi, Giuseppe Galluzzi, Fiorella Salti, Roberto Vierucci, Alberto |
| description | Spontaneous and phytohemagglutinin (PHA)-stimulated interleukin (IL)-6 release by cultured peripheral blood mononuclear cells was related to height velocity, bone age, insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3) serum level standard deviation scores (SDS) of 32 children [aged 91 (median; range 13–151) months] with human immunodeficiency virus-type 1 (HIV-1) perinatal infection and severe disease. Spontaneous and PHA-stimulated IL-6 release inversely correlated with height velocity, bone age, IGF-I, and IGFBP-3 SDS. Ten children with height velocity SDS ≤ −2, compared to 22 children with height velocity SDS > −2, showed higher spontaneous and PHA-stimulated IL-6 release and lower IGF-I and IGFBP-3 SDS (irrespective of CD4-positive T-lymphocyte counts, viral load, liver disease, or nutrition status). IL-6 overproduction may be a mechanism of IGF-I and IGFBP-3 down-regulation and impaired linear growth in children with perinatal HIV-1 infection. Growth-promoting strategies, including targeted anticytokine treatments, could be devised for such children. |
| doi_str_mv | 10.1006/clim.2000.4838 |
| format | Article |
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Spontaneous and PHA-stimulated IL-6 release inversely correlated with height velocity, bone age, IGF-I, and IGFBP-3 SDS. Ten children with height velocity SDS ≤ −2, compared to 22 children with height velocity SDS > −2, showed higher spontaneous and PHA-stimulated IL-6 release and lower IGF-I and IGFBP-3 SDS (irrespective of CD4-positive T-lymphocyte counts, viral load, liver disease, or nutrition status). IL-6 overproduction may be a mechanism of IGF-I and IGFBP-3 down-regulation and impaired linear growth in children with perinatal HIV-1 infection. Growth-promoting strategies, including targeted anticytokine treatments, could be devised for such children.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1006/clim.2000.4838</identifier><identifier>PMID: 10692240</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Age Determination by Skeleton ; AIDS/HIV ; Biological and medical sciences ; Body Height ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes ; Cells, Cultured ; Child, Preschool ; children ; Cross-Sectional Studies ; Growth Disorders - blood ; HIV Seropositivity - congenital ; HIV-1 ; Human viral diseases ; Humans ; IGF-I ; IGFBP-3 ; IL-6 ; Infectious diseases ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor I - analysis ; Interleukin-6 - blood ; Interleukin-6 - metabolism ; Leukocytes, Mononuclear - cytology ; Leukocytes, Mononuclear - metabolism ; linear growth ; Liver Diseases - complications ; Medical sciences ; Nutritional Status ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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Spontaneous and PHA-stimulated IL-6 release inversely correlated with height velocity, bone age, IGF-I, and IGFBP-3 SDS. Ten children with height velocity SDS ≤ −2, compared to 22 children with height velocity SDS > −2, showed higher spontaneous and PHA-stimulated IL-6 release and lower IGF-I and IGFBP-3 SDS (irrespective of CD4-positive T-lymphocyte counts, viral load, liver disease, or nutrition status). IL-6 overproduction may be a mechanism of IGF-I and IGFBP-3 down-regulation and impaired linear growth in children with perinatal HIV-1 infection. Growth-promoting strategies, including targeted anticytokine treatments, could be devised for such children.</description><subject>Age Determination by Skeleton</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Body Height</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-Positive T-Lymphocytes</subject><subject>Cells, Cultured</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Cross-Sectional Studies</subject><subject>Growth Disorders - blood</subject><subject>HIV Seropositivity - congenital</subject><subject>HIV-1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>IGF-I</subject><subject>IGFBP-3</subject><subject>IL-6</subject><subject>Infectious diseases</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - blood</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - metabolism</subject><subject>Leukocytes, Mononuclear - cytology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>linear growth</subject><subject>Liver Diseases - complications</subject><subject>Medical sciences</subject><subject>Nutritional Status</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Aids</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Martino, Maurizio</creatorcontrib><creatorcontrib>Galli, Luisa</creatorcontrib><creatorcontrib>Chiarelli, Francesco</creatorcontrib><creatorcontrib>Verrotti, Alberto</creatorcontrib><creatorcontrib>Rossi, Maria Elisabetta</creatorcontrib><creatorcontrib>Bindi, Giuseppe</creatorcontrib><creatorcontrib>Galluzzi, Fiorella</creatorcontrib><creatorcontrib>Salti, Roberto</creatorcontrib><creatorcontrib>Vierucci, Alberto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Martino, Maurizio</au><au>Galli, Luisa</au><au>Chiarelli, Francesco</au><au>Verrotti, Alberto</au><au>Rossi, Maria Elisabetta</au><au>Bindi, Giuseppe</au><au>Galluzzi, Fiorella</au><au>Salti, Roberto</au><au>Vierucci, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-6 Release by Cultured Peripheral Blood Mononuclear Cells Inversely Correlates with Height Velocity, Bone Age, Insulin-like Growth Factor-I, and Insulin-like Growth Factor Binding Protein-3 Serum Levels in Children with Perinatal HIV-1 Infection</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>94</volume><issue>3</issue><spage>212</spage><epage>218</epage><pages>212-218</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><coden>CLIIFY</coden><abstract>Spontaneous and phytohemagglutinin (PHA)-stimulated interleukin (IL)-6 release by cultured peripheral blood mononuclear cells was related to height velocity, bone age, insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3) serum level standard deviation scores (SDS) of 32 children [aged 91 (median; range 13–151) months] with human immunodeficiency virus-type 1 (HIV-1) perinatal infection and severe disease. Spontaneous and PHA-stimulated IL-6 release inversely correlated with height velocity, bone age, IGF-I, and IGFBP-3 SDS. Ten children with height velocity SDS ≤ −2, compared to 22 children with height velocity SDS > −2, showed higher spontaneous and PHA-stimulated IL-6 release and lower IGF-I and IGFBP-3 SDS (irrespective of CD4-positive T-lymphocyte counts, viral load, liver disease, or nutrition status). IL-6 overproduction may be a mechanism of IGF-I and IGFBP-3 down-regulation and impaired linear growth in children with perinatal HIV-1 infection. Growth-promoting strategies, including targeted anticytokine treatments, could be devised for such children.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>10692240</pmid><doi>10.1006/clim.2000.4838</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1521-6616 |
| ispartof | Clinical immunology (Orlando, Fla.), 2000-03, Vol.94 (3), p.212-218 |
| issn | 1521-6616 1521-7035 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Age Determination by Skeleton AIDS/HIV Biological and medical sciences Body Height CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Cells, Cultured Child, Preschool children Cross-Sectional Studies Growth Disorders - blood HIV Seropositivity - congenital HIV-1 Human viral diseases Humans IGF-I IGFBP-3 IL-6 Infectious diseases Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - analysis Interleukin-6 - blood Interleukin-6 - metabolism Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - metabolism linear growth Liver Diseases - complications Medical sciences Nutritional Status Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load |
| title | Interleukin-6 Release by Cultured Peripheral Blood Mononuclear Cells Inversely Correlates with Height Velocity, Bone Age, Insulin-like Growth Factor-I, and Insulin-like Growth Factor Binding Protein-3 Serum Levels in Children with Perinatal HIV-1 Infection |
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