Stat6 Regulation of In Vivo IL-4 Responses

Although in vitro development of a Th2 response from naive CD4+ T cells is Stat6 dependent, mice immunized with a goat Ab to mouse IgD have been reported to produce a normal primary IL-4 response in Stat6-deficient mice. Experiments have now been performed with mice immunized with more conventional...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-03, Vol.164 (5), p.2303-2310
Hauptverfasser:	Finkelman, Fred D, Morris, Suzanne C, Orekhova, Tatyana, Mori, Masaaki, Donaldson, Debra, Reiner, Steven L, Reilly, Nancy L, Schopf, Lisa, Urban, Joseph F., Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Antibodies - physiology Antibodies, Monoclonal - administration & dosage CD3 Complex - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Chickens Female Goats Immunoglobulin D - administration & dosage Immunologic Memory Injections, Intravenous Interleukin-4 - antagonists & inhibitors Interleukin-4 - biosynthesis Intestinal Diseases, Parasitic - immunology Male Mast Cells - immunology Mast Cells - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Nematospiroides dubius - immunology Nippostrongylus - immunology Ovalbumin - administration & dosage Ovalbumin - immunology Receptors, Interleukin-4 - deficiency Receptors, Interleukin-4 - genetics Signal Transduction - immunology Stat6 protein STAT6 Transcription Factor Strongylida Infections - immunology Th2 Cells - immunology Th2 Cells - metabolism Trans-Activators - deficiency Trans-Activators - genetics Trans-Activators - physiology Trichinella spiralis - immunology Trichinellosis - immunology
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