Cadmium Effects on Hypothalamic-Pituitary-Testicular Axis in Male Rats
This study analyzes cadmium effects at the hypothalamic-pituitary-testicular axis. Male rats were given cadmium during puberty or adulthood. Cadmium exposure through puberty increased norepinephrine content in all hypothalamic areas studied, but not in the median eminence. Metal exposure increased s...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 2001-06, Vol.226 (6), p.605-611 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
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| creator | Lafuente, Anunciación Márquez, Nuria Pérez-Lorenzo, María Pazo, David Esquifino, Ana I. |
| description | This study analyzes cadmium effects at the hypothalamic-pituitary-testicular axis. Male rats were given cadmium during puberty or adulthood. Cadmium exposure through puberty increased norepinephrine content in all hypothalamic areas studied, but not in the median eminence. Metal exposure increased serotonin turnover in median eminence and the anterior hypothalamus, while decreased it in mediobasal hypothalamus. Also, decreased plasma levels of testosterone were found. Cadmium exposure during adulthood increased norepinephrine content in posterior hypothalamus and decreased the neurotransmitter content in anterior and mediobasal hypothalamus. Decreased circulating levels of luteinizing hormone (LH) and testosterone and increased plasma follicle stimulating hormone (FSH) levels were also observed. Cadmium accumulated in all analyzed tissues. Various parameters showed age-dependent changes. These data suggest that cadmium globally effects hypothalamic-pituitary-testicular axis function by acting at the three levels analyzed and that an interaction between cadmium exposure and age emerge. |
| doi_str_mv | 10.1177/153537020122600615 |
| format | Article |
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Male rats were given cadmium during puberty or adulthood. Cadmium exposure through puberty increased norepinephrine content in all hypothalamic areas studied, but not in the median eminence. Metal exposure increased serotonin turnover in median eminence and the anterior hypothalamus, while decreased it in mediobasal hypothalamus. Also, decreased plasma levels of testosterone were found. Cadmium exposure during adulthood increased norepinephrine content in posterior hypothalamus and decreased the neurotransmitter content in anterior and mediobasal hypothalamus. Decreased circulating levels of luteinizing hormone (LH) and testosterone and increased plasma follicle stimulating hormone (FSH) levels were also observed. Cadmium accumulated in all analyzed tissues. Various parameters showed age-dependent changes. These data suggest that cadmium globally effects hypothalamic-pituitary-testicular axis function by acting at the three levels analyzed and that an interaction between cadmium exposure and age emerge.</description><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.1177/153537020122600615</identifier><identifier>PMID: 11395933</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Cadmium - metabolism ; Cadmium - pharmacology ; Follicle Stimulating Hormone - blood ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; Luteinizing Hormone - blood ; Male ; Norepinephrine - metabolism ; Pituitary Gland - drug effects ; Pituitary Gland - metabolism ; Rats ; Rats, Sprague-Dawley ; Serotonin - metabolism ; Testis - drug effects ; Testis - metabolism ; Testosterone - blood</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 2001-06, Vol.226 (6), p.605-611</ispartof><rights>2001 by the Society for Experimental Biology and Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-ba13a72e87ea53b2c71690defc8c6a264abe1bb317415d3c48d99b7aff3da4a13</citedby><cites>FETCH-LOGICAL-c339t-ba13a72e87ea53b2c71690defc8c6a264abe1bb317415d3c48d99b7aff3da4a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11395933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lafuente, Anunciación</creatorcontrib><creatorcontrib>Márquez, Nuria</creatorcontrib><creatorcontrib>Pérez-Lorenzo, María</creatorcontrib><creatorcontrib>Pazo, David</creatorcontrib><creatorcontrib>Esquifino, Ana I.</creatorcontrib><title>Cadmium Effects on Hypothalamic-Pituitary-Testicular Axis in Male Rats</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Exp Biol Med (Maywood)</addtitle><description>This study analyzes cadmium effects at the hypothalamic-pituitary-testicular axis. Male rats were given cadmium during puberty or adulthood. Cadmium exposure through puberty increased norepinephrine content in all hypothalamic areas studied, but not in the median eminence. Metal exposure increased serotonin turnover in median eminence and the anterior hypothalamus, while decreased it in mediobasal hypothalamus. Also, decreased plasma levels of testosterone were found. Cadmium exposure during adulthood increased norepinephrine content in posterior hypothalamus and decreased the neurotransmitter content in anterior and mediobasal hypothalamus. Decreased circulating levels of luteinizing hormone (LH) and testosterone and increased plasma follicle stimulating hormone (FSH) levels were also observed. Cadmium accumulated in all analyzed tissues. Various parameters showed age-dependent changes. These data suggest that cadmium globally effects hypothalamic-pituitary-testicular axis function by acting at the three levels analyzed and that an interaction between cadmium exposure and age emerge.</description><subject>Animals</subject><subject>Cadmium - metabolism</subject><subject>Cadmium - pharmacology</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Norepinephrine - metabolism</subject><subject>Pituitary Gland - drug effects</subject><subject>Pituitary Gland - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serotonin - metabolism</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Testosterone - blood</subject><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotla_gAfJydtqJtlNNsdSWitUFKnnZTab1ZT9Uze7YL-9Ka14EDzNMPzeY94j5BrYHYBS95CIRCjGGXAuGZOQnJDx_hgJqfXpzx6IEbnwfsMYJIrLczICEDrRQozJYoZF7YaazsvSmt7TtqHL3bbtP7DC2pnoxfWD67HbRWvre2eGCjs6_XKeuoY-YWXpK_b-kpyVWHl7dZwT8raYr2fLaPX88DibriIjhO6jHEGg4jZVFhORc6NAalbY0qRGIpcx5hbyXICKISmEidNC61xhWYoC4yCekNuD77ZrP4fwUFY7b2xVYWPbwWeKaZYKLQPID6DpWu87W2bbztUhRgYs27eX_W0viG6O7kNe2-JXcqwrAPcHwOO7zTbt0DUh7X-W3w_4d18</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Lafuente, Anunciación</creator><creator>Márquez, Nuria</creator><creator>Pérez-Lorenzo, María</creator><creator>Pazo, David</creator><creator>Esquifino, Ana I.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Cadmium Effects on Hypothalamic-Pituitary-Testicular Axis in Male Rats</title><author>Lafuente, Anunciación ; Márquez, Nuria ; Pérez-Lorenzo, María ; Pazo, David ; Esquifino, Ana I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-ba13a72e87ea53b2c71690defc8c6a264abe1bb317415d3c48d99b7aff3da4a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Cadmium - metabolism</topic><topic>Cadmium - pharmacology</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Norepinephrine - metabolism</topic><topic>Pituitary Gland - drug effects</topic><topic>Pituitary Gland - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serotonin - metabolism</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lafuente, Anunciación</creatorcontrib><creatorcontrib>Márquez, Nuria</creatorcontrib><creatorcontrib>Pérez-Lorenzo, María</creatorcontrib><creatorcontrib>Pazo, David</creatorcontrib><creatorcontrib>Esquifino, Ana I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lafuente, Anunciación</au><au>Márquez, Nuria</au><au>Pérez-Lorenzo, María</au><au>Pazo, David</au><au>Esquifino, Ana I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cadmium Effects on Hypothalamic-Pituitary-Testicular Axis in Male Rats</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Exp Biol Med (Maywood)</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>226</volume><issue>6</issue><spage>605</spage><epage>611</epage><pages>605-611</pages><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>This study analyzes cadmium effects at the hypothalamic-pituitary-testicular axis. Male rats were given cadmium during puberty or adulthood. Cadmium exposure through puberty increased norepinephrine content in all hypothalamic areas studied, but not in the median eminence. Metal exposure increased serotonin turnover in median eminence and the anterior hypothalamus, while decreased it in mediobasal hypothalamus. Also, decreased plasma levels of testosterone were found. Cadmium exposure during adulthood increased norepinephrine content in posterior hypothalamus and decreased the neurotransmitter content in anterior and mediobasal hypothalamus. Decreased circulating levels of luteinizing hormone (LH) and testosterone and increased plasma follicle stimulating hormone (FSH) levels were also observed. Cadmium accumulated in all analyzed tissues. Various parameters showed age-dependent changes. These data suggest that cadmium globally effects hypothalamic-pituitary-testicular axis function by acting at the three levels analyzed and that an interaction between cadmium exposure and age emerge.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>11395933</pmid><doi>10.1177/153537020122600615</doi><tpages>7</tpages></addata></record> |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 2001-06, Vol.226 (6), p.605-611 |
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| subjects | Animals Cadmium - metabolism Cadmium - pharmacology Follicle Stimulating Hormone - blood Hypothalamus - drug effects Hypothalamus - metabolism Luteinizing Hormone - blood Male Norepinephrine - metabolism Pituitary Gland - drug effects Pituitary Gland - metabolism Rats Rats, Sprague-Dawley Serotonin - metabolism Testis - drug effects Testis - metabolism Testosterone - blood |
| title | Cadmium Effects on Hypothalamic-Pituitary-Testicular Axis in Male Rats |
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