Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (sln) after duodenal administration to rats. Part II—Tissue distribution

Tobramycin-loaded solid lipid nanoparticles (SLN) were prepared and administered by duodenal and intravenous (i.v.) routes to rats and the tissue distributions were determined successively at fixed times (30 min, 4 h and 24 h) and compared to those of the tobramycin solution after i.v. administratio...

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Veröffentlicht in:	Pharmacological research 2001-05, Vol.43 (5), p.497-502
Hauptverfasser:	Bargoni, Alessandro, Cavalli, Roberta, Zara, Gian Paolo, Fundarò, Anna, Caputo, Otto, Gasco, Maria Rosa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Drug Carriers duodenal administration, intravenous administration, tobramycin-loaded solid lipid nanoparticles, tobramycin tissue distribution, blood–brain barrier Duodenum - physiology Injections Injections, Intravenous Intestinal Absorption Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Liposomes Male Pharmaceutical Solutions Rats Rats, Wistar Tissue Distribution Tobramycin - administration & dosage Tobramycin - pharmacokinetics
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