Endothelial Dysfunction and Elevation of S-Adenosylhomocysteine in Cystathionine β-Synthase–Deficient Mice

Hyperhomocysteinemia is associated with increased risk for cardiovascular events, but it is not certain whether it is a mediator of vascular dysfunction or a marker for another risk factor. Homocysteine levels are regulated by folate bioavailability and also by the methyl donor S-adenosylmethionine...

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Veröffentlicht in:	Circulation research 2001-06, Vol.88 (11), p.1203-1209
Hauptverfasser:	Dayal, Sanjana, Bottiglieri, Teodoro, Arning, Erland, Maeda, Nobuyo, Malinow, M René, Sigmund, Curt D, Heistad, Donald D, Faraci, Frank M, Lentz, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacid disorders Animals Aorta - drug effects Aorta - metabolism Aorta - physiopathology Biological and medical sciences Brain - metabolism Chronic Disease Cystathionine beta-Synthase - deficiency Cystathionine beta-Synthase - genetics Disease Models, Animal Endothelium, Vascular - physiopathology Errors of metabolism Folic Acid - blood Food, Fortified Heterozygote Homocysteine - blood Hyperhomocysteinemia - blood Hyperhomocysteinemia - physiopathology In Vitro Techniques Liver - metabolism Medical sciences Metabolic diseases Methionine - blood Methylation Mice Mice, Inbred C57BL Mice, Knockout S-Adenosylhomocysteine - metabolism S-Adenosylmethionine - metabolism Thrombomodulin - metabolism Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology Vasomotor System - drug effects Vasomotor System - physiopathology
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