Analysis of variation in plasma concentrations of nelfinavir and its active metabolite M8 in HIV-positive patients

To characterize sources of variation in plasma concentrations of nelfinavir and its active metabolite M8 and to evaluate the use of therapeutic drug monitoring for nelfinavir treatment. Plasma samples and patient's characteristics were obtained from outpatient clinic. Differences between groups...

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Veröffentlicht in:	AIDS (London) 2001-05, Vol.15 (8), p.991-998
Hauptverfasser:	BAEDE-VAN DIJK, Patricia A, HUGEN, Patricia W. H, VERWEIJ-VAN WISSEN, Corrien P. W. G. M, KOOPMANS, Peter P, BURGER, David M, HEKSTER, Yechiel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Aryl Hydrocarbon Hydroxylases Biological and medical sciences Body Weight Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - biosynthesis Databases, Factual Diarrhea - drug therapy Dose-Response Relationship, Drug Drug Therapy, Combination Enzyme Induction Enzyme Inhibitors - therapeutic use Female HIV Infections - drug therapy HIV Infections - metabolism HIV Protease Inhibitors - blood HIV Protease Inhibitors - metabolism HIV Protease Inhibitors - therapeutic use HIV Seropositivity Human immunodeficiency virus Humans Male Medical sciences Middle Aged Mixed Function Oxygenases - antagonists & inhibitors Mixed Function Oxygenases - biosynthesis nelfinavir Nelfinavir - blood Nelfinavir - metabolism Nelfinavir - therapeutic use Omeprazole - therapeutic use Pharmacology. Drug treatments
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