Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

Orexins (hypocretins) are a pair of neuropeptides implicated in energy homeostasis and arousal. Recent reports suggest that loss of orexin-containing neurons occurs in human patients with narcolepsy. We generated transgenic mice in which orexin-containing neurons are ablated by orexinergic-specific...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2001-05, Vol.30 (2), p.345-354
Hauptverfasser:	Hara, Junko, Beuckmann, Carsten T., Nambu, Tadahiro, Willie, Jon T., Chemelli, Richard M., Sinton, Christopher M., Sugiyama, Fumihiro, Yagami, Ken-ichi, Goto, Katsutoshi, Yanagisawa, Masashi, Sakurai, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxin-3 Carrier Proteins - metabolism Feeding and Eating Disorders - genetics Feeding and Eating Disorders - physiopathology Female Humans Hypothalamus - pathology Hypothalamus - physiopathology Intracellular Signaling Peptides and Proteins Machado-Joseph Disease - genetics Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Narcolepsy - genetics Narcolepsy - physiopathology Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - pathology Neurons - physiology Neuropeptides - metabolism Neurotransmitter Agents - metabolism Nuclear Proteins Obesity - genetics Obesity - physiopathology Orexins Peptides - genetics Repressor Proteins Sequence Deletion Sleep Stages - genetics Sleep Stages - physiology Sleep, REM - genetics Transcription Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!