T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major
In thalassaemic patients, neurophysiological disturbances have been associated with high serum ferritin levels and desferrioxamine therapy. In the presence of a magnetic field, ferritin, the main iron storage protein, induces a preferential decrease of the T(2) relaxation time. The purpose of this s...
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| Veröffentlicht in: | British journal of radiology 2001-05, Vol.74 (881), p.407-410 |
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| creator | Metafratzi, Z Argyropoulou, M I Kiortsis, D N Tsampoulas, C Chaliassos, N Efremidis, S C |
| description | In thalassaemic patients, neurophysiological disturbances have been associated with high serum ferritin levels and desferrioxamine therapy. In the presence of a magnetic field, ferritin, the main iron storage protein, induces a preferential decrease of the T(2) relaxation time. The purpose of this study was to evaluate thalassaemic patients for brain iron deposition by assessing the T(2) relaxation rate (1/T(2)) of the grey matter. 41 thalassaemic patients (age range 8.5-44 years, mean 24 years) and 58 age- and sex-matched controls were included in the study. Current serum ferritin levels were obtained. The 1/T(2) values of the cortex (motor and temporal) (mean 0.0122 ms(-1), SD 0.0004), putamen (mean 0.0137 ms(-1), SD 0.0004) and caudate nucleus (mean 0.0132 ms(-1), SD 0.0003) were higher in patients compared with the controls (mean 0.0110 ms(-1), SD 0.0004; mean 0.0120 ms(-1), SD 0.0005; mean 0.0117 ms(-1), SD 0.0003, respectively) (p |
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In the presence of a magnetic field, ferritin, the main iron storage protein, induces a preferential decrease of the T(2) relaxation time. The purpose of this study was to evaluate thalassaemic patients for brain iron deposition by assessing the T(2) relaxation rate (1/T(2)) of the grey matter. 41 thalassaemic patients (age range 8.5-44 years, mean 24 years) and 58 age- and sex-matched controls were included in the study. Current serum ferritin levels were obtained. The 1/T(2) values of the cortex (motor and temporal) (mean 0.0122 ms(-1), SD 0.0004), putamen (mean 0.0137 ms(-1), SD 0.0004) and caudate nucleus (mean 0.0132 ms(-1), SD 0.0003) were higher in patients compared with the controls (mean 0.0110 ms(-1), SD 0.0004; mean 0.0120 ms(-1), SD 0.0005; mean 0.0117 ms(-1), SD 0.0003, respectively) (p<0.001 for all parameters). No statistically significant differences were found in the globus pallidus. No correlation was found between 1/T(2) and serum ferritin. The higher values of 1/T(2) in the cortex, putamen and caudate nucleus of thalassaemic patients probably reflect a higher iron deposition. The lack of differences in 1/T(2) of the globus pallidus might suggest that even in thalassaemic patients iron cannot exceed a saturation level.</description><identifier>ISSN: 0007-1285</identifier><identifier>PMID: 11388988</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Basal Ganglia - metabolism ; beta-Thalassemia - blood ; beta-Thalassemia - complications ; beta-Thalassemia - diagnosis ; Blood-Brain Barrier - physiology ; Case-Control Studies ; Cerebral Cortex - metabolism ; Child ; Female ; Ferritins - analysis ; Ferritins - metabolism ; Humans ; Iron Overload - complications ; Iron Overload - diagnosis ; Iron Overload - metabolism ; Magnetic Resonance Imaging - methods ; Male ; Statistics, Nonparametric</subject><ispartof>British journal of radiology, 2001-05, Vol.74 (881), p.407-410</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11388988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metafratzi, Z</creatorcontrib><creatorcontrib>Argyropoulou, M I</creatorcontrib><creatorcontrib>Kiortsis, D N</creatorcontrib><creatorcontrib>Tsampoulas, C</creatorcontrib><creatorcontrib>Chaliassos, N</creatorcontrib><creatorcontrib>Efremidis, S C</creatorcontrib><title>T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major</title><title>British journal of radiology</title><addtitle>Br J Radiol</addtitle><description>In thalassaemic patients, neurophysiological disturbances have been associated with high serum ferritin levels and desferrioxamine therapy. In the presence of a magnetic field, ferritin, the main iron storage protein, induces a preferential decrease of the T(2) relaxation time. The purpose of this study was to evaluate thalassaemic patients for brain iron deposition by assessing the T(2) relaxation rate (1/T(2)) of the grey matter. 41 thalassaemic patients (age range 8.5-44 years, mean 24 years) and 58 age- and sex-matched controls were included in the study. Current serum ferritin levels were obtained. The 1/T(2) values of the cortex (motor and temporal) (mean 0.0122 ms(-1), SD 0.0004), putamen (mean 0.0137 ms(-1), SD 0.0004) and caudate nucleus (mean 0.0132 ms(-1), SD 0.0003) were higher in patients compared with the controls (mean 0.0110 ms(-1), SD 0.0004; mean 0.0120 ms(-1), SD 0.0005; mean 0.0117 ms(-1), SD 0.0003, respectively) (p<0.001 for all parameters). No statistically significant differences were found in the globus pallidus. No correlation was found between 1/T(2) and serum ferritin. The higher values of 1/T(2) in the cortex, putamen and caudate nucleus of thalassaemic patients probably reflect a higher iron deposition. The lack of differences in 1/T(2) of the globus pallidus might suggest that even in thalassaemic patients iron cannot exceed a saturation level.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Basal Ganglia - metabolism</subject><subject>beta-Thalassemia - blood</subject><subject>beta-Thalassemia - complications</subject><subject>beta-Thalassemia - diagnosis</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Case-Control Studies</subject><subject>Cerebral Cortex - metabolism</subject><subject>Child</subject><subject>Female</subject><subject>Ferritins - analysis</subject><subject>Ferritins - metabolism</subject><subject>Humans</subject><subject>Iron Overload - complications</subject><subject>Iron Overload - diagnosis</subject><subject>Iron Overload - metabolism</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Statistics, Nonparametric</subject><issn>0007-1285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10EtLw0AUBeBZKLZW_4LMSnQRmEcyj6UUtULBTTeuws3kpk2ZPJyZYP33Rqyry4GPw-FekCVjTGdcmGJBrmM8_sbCsiuy4FwaY41Zko_dg3ikAT2cILVDTwMkpENDK4jg6R76vW-BQl9TN4SEJ9r2dJwp9inSrzYdaIUJsnQADzECdrPu4DiEG3LZgI94e74rsnt53q032fb99W39tM3GIjdZBbmbtxiVC4kFb9Byx4WtayuLXDI0mgklcuG0ZtwJ7WrFG6cqVcicWZByRe7_ascwfE4YU9m10aH30OMwxVIzyxS3eoZ3ZzhVHdblGNoOwnf5_wv5A8z7WJE</recordid><startdate>200105</startdate><enddate>200105</enddate><creator>Metafratzi, Z</creator><creator>Argyropoulou, M I</creator><creator>Kiortsis, D N</creator><creator>Tsampoulas, C</creator><creator>Chaliassos, N</creator><creator>Efremidis, S C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200105</creationdate><title>T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major</title><author>Metafratzi, Z ; Argyropoulou, M I ; Kiortsis, D N ; Tsampoulas, C ; Chaliassos, N ; Efremidis, S C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p548-ba4c38886423e51fe91c129dd935430e87026242c7701c27cd61fc6b653409a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Basal Ganglia - metabolism</topic><topic>beta-Thalassemia - blood</topic><topic>beta-Thalassemia - complications</topic><topic>beta-Thalassemia - diagnosis</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Case-Control Studies</topic><topic>Cerebral Cortex - metabolism</topic><topic>Child</topic><topic>Female</topic><topic>Ferritins - analysis</topic><topic>Ferritins - metabolism</topic><topic>Humans</topic><topic>Iron Overload - complications</topic><topic>Iron Overload - diagnosis</topic><topic>Iron Overload - metabolism</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metafratzi, Z</creatorcontrib><creatorcontrib>Argyropoulou, M I</creatorcontrib><creatorcontrib>Kiortsis, D N</creatorcontrib><creatorcontrib>Tsampoulas, C</creatorcontrib><creatorcontrib>Chaliassos, N</creatorcontrib><creatorcontrib>Efremidis, S C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metafratzi, Z</au><au>Argyropoulou, M I</au><au>Kiortsis, D N</au><au>Tsampoulas, C</au><au>Chaliassos, N</au><au>Efremidis, S C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major</atitle><jtitle>British journal of radiology</jtitle><addtitle>Br J Radiol</addtitle><date>2001-05</date><risdate>2001</risdate><volume>74</volume><issue>881</issue><spage>407</spage><epage>410</epage><pages>407-410</pages><issn>0007-1285</issn><abstract>In thalassaemic patients, neurophysiological disturbances have been associated with high serum ferritin levels and desferrioxamine therapy. In the presence of a magnetic field, ferritin, the main iron storage protein, induces a preferential decrease of the T(2) relaxation time. The purpose of this study was to evaluate thalassaemic patients for brain iron deposition by assessing the T(2) relaxation rate (1/T(2)) of the grey matter. 41 thalassaemic patients (age range 8.5-44 years, mean 24 years) and 58 age- and sex-matched controls were included in the study. Current serum ferritin levels were obtained. The 1/T(2) values of the cortex (motor and temporal) (mean 0.0122 ms(-1), SD 0.0004), putamen (mean 0.0137 ms(-1), SD 0.0004) and caudate nucleus (mean 0.0132 ms(-1), SD 0.0003) were higher in patients compared with the controls (mean 0.0110 ms(-1), SD 0.0004; mean 0.0120 ms(-1), SD 0.0005; mean 0.0117 ms(-1), SD 0.0003, respectively) (p<0.001 for all parameters). No statistically significant differences were found in the globus pallidus. No correlation was found between 1/T(2) and serum ferritin. The higher values of 1/T(2) in the cortex, putamen and caudate nucleus of thalassaemic patients probably reflect a higher iron deposition. The lack of differences in 1/T(2) of the globus pallidus might suggest that even in thalassaemic patients iron cannot exceed a saturation level.</abstract><cop>England</cop><pmid>11388988</pmid><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Basal Ganglia - metabolism beta-Thalassemia - blood beta-Thalassemia - complications beta-Thalassemia - diagnosis Blood-Brain Barrier - physiology Case-Control Studies Cerebral Cortex - metabolism Child Female Ferritins - analysis Ferritins - metabolism Humans Iron Overload - complications Iron Overload - diagnosis Iron Overload - metabolism Magnetic Resonance Imaging - methods Male Statistics, Nonparametric |
| title | T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major |
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