Differing Effects of Endocrine-Disrupting Chemicals on Basal and FSH-Stimulated Progesterone Production in Rat Granulosa-Luteal Cells

Previous studies have shown that the phytoestrogen, genistein, inhibits basal and forskolin-stimulated progesterone synthesis in rat granulosa-luteal cells. Genistein, however, not only binds and activates the estrogen receptor (ER), but is also a potent inhibitor of tyrosine kinase. In these studie...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2001-06, Vol.226 (6), p.570-576
Hauptverfasser:	Nejaty, Hedieh, Lacey, Michael, Whitehead, Saffron A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apigenin Cells, Cultured Colforsin - pharmacology Coumarins - pharmacology DDT - pharmacology Estradiol - pharmacology Estrogens - pharmacology Female Flavonoids - pharmacology Follicle Stimulating Hormone - pharmacology Genistein - pharmacology Granulosa Cells - cytology Granulosa Cells - drug effects Granulosa Cells - metabolism Phenols - pharmacology Progesterone - biosynthesis Rats Rats, Wistar
Online-Zugang:	Volltext
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