Signaling by extracellular nucleotides in anterior pituitary cells
Pituitary cells secrete ATP, which acts as an autocrine and/or paracrine extracellular messenger on two families of purinergic receptors: G-protein-coupled P2Y receptors (P2YRs) and ion-conducting P2X receptors (P2XRs). Lactotrophs and GH 3-immortalized cells express the P2Y 2R subtype. Several P2XR...
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| Veröffentlicht in: | Trends in Endocrinology & Metabolism 2001-07, Vol.12 (5), p.218-225 |
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| creator | Stojilkovic, Stanko S Koshimizu, Taka-aki |
| description | Pituitary cells secrete ATP, which acts as an autocrine and/or paracrine extracellular messenger on two families of purinergic receptors: G-protein-coupled P2Y receptors (P2YRs) and ion-conducting P2X receptors (P2XRs). Lactotrophs and GH
3-immortalized cells express the P2Y
2R subtype. Several P2XR subtypes are expressed in pituitary cells. Gonadotrophs and somatotrophs express P2X
2aR and P2X
2bR, which occur as heteromeric channels. Lactotrophs and GH
3 cells express one or more ion-conducting subtypes from among P2X
3R, P2X
4R and P2X
7R in homomeric form. Thyrotrophs and corticotrophs also express P2XRs, but their identification requires further study. Pituitary cells express purinergic P1 receptors, which are activated by adenosine. The A
1R subtype of these receptors is expressed in melanotrophs and GH
3 cells. In this review, we briefly discuss the expression and coupling of A
1R and P2Y
2R, and focus on the expression and Ca
2+ signaling of P2XRs. |
| doi_str_mv | 10.1016/S1043-2760(01)00387-3 |
| format | Article |
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2R subtype. Several P2XR subtypes are expressed in pituitary cells. Gonadotrophs and somatotrophs express P2X
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2bR, which occur as heteromeric channels. Lactotrophs and GH
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1R subtype of these receptors is expressed in melanotrophs and GH
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1R and P2Y
2R, and focus on the expression and Ca
2+ signaling of P2XRs.</description><identifier>ISSN: 1043-2760</identifier><identifier>EISSN: 1879-3061</identifier><identifier>DOI: 10.1016/S1043-2760(01)00387-3</identifier><identifier>PMID: 11397647</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adenosine Triphosphate - metabolism ; Adenosine Triphosphate - secretion ; Animals ; anterior pituitary ; ATP ; Autocrine Communication ; Biological and medical sciences ; Calcium Signaling ; extracellular nucleotides ; Fundamental and applied biological sciences. Psychology ; Gonadotrophs ; Heterotrimeric GTP-Binding Proteins - metabolism ; Hormones and neuropeptides. Regulation ; Humans ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Lactotophs ; Paracrine Communication ; Pituitary Gland, Anterior - cytology ; Pituitary Gland, Anterior - metabolism ; Pituitary Gland, Anterior - secretion ; Receptors, Purinergic P1 - metabolism ; Receptors, Purinergic P2 - chemistry ; Receptors, Purinergic P2 - genetics ; Receptors, Purinergic P2 - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; signaling ; somatotrophs ; Vertebrates: endocrinology</subject><ispartof>Trends in Endocrinology & Metabolism, 2001-07, Vol.12 (5), p.218-225</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-e4d92a1f7c92b4008ef50d1236c5b4bcb5df14a47b73898976dca0cba41f55753</citedby><cites>FETCH-LOGICAL-c503t-e4d92a1f7c92b4008ef50d1236c5b4bcb5df14a47b73898976dca0cba41f55753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1043276001003873$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,776,780,788,3537,27899,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1092137$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11397647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stojilkovic, Stanko S</creatorcontrib><creatorcontrib>Koshimizu, Taka-aki</creatorcontrib><title>Signaling by extracellular nucleotides in anterior pituitary cells</title><title>Trends in Endocrinology & Metabolism</title><addtitle>Trends Endocrinol Metab</addtitle><description>Pituitary cells secrete ATP, which acts as an autocrine and/or paracrine extracellular messenger on two families of purinergic receptors: G-protein-coupled P2Y receptors (P2YRs) and ion-conducting P2X receptors (P2XRs). Lactotrophs and GH
3-immortalized cells express the P2Y
2R subtype. Several P2XR subtypes are expressed in pituitary cells. Gonadotrophs and somatotrophs express P2X
2aR and P2X
2bR, which occur as heteromeric channels. Lactotrophs and GH
3 cells express one or more ion-conducting subtypes from among P2X
3R, P2X
4R and P2X
7R in homomeric form. Thyrotrophs and corticotrophs also express P2XRs, but their identification requires further study. Pituitary cells express purinergic P1 receptors, which are activated by adenosine. The A
1R subtype of these receptors is expressed in melanotrophs and GH
3 cells. In this review, we briefly discuss the expression and coupling of A
1R and P2Y
2R, and focus on the expression and Ca
2+ signaling of P2XRs.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Adenosine Triphosphate - secretion</subject><subject>Animals</subject><subject>anterior pituitary</subject><subject>ATP</subject><subject>Autocrine Communication</subject><subject>Biological and medical sciences</subject><subject>Calcium Signaling</subject><subject>extracellular nucleotides</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadotrophs</subject><subject>Heterotrimeric GTP-Binding Proteins - metabolism</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Lactotophs</subject><subject>Paracrine Communication</subject><subject>Pituitary Gland, Anterior - cytology</subject><subject>Pituitary Gland, Anterior - metabolism</subject><subject>Pituitary Gland, Anterior - secretion</subject><subject>Receptors, Purinergic P1 - metabolism</subject><subject>Receptors, Purinergic P2 - chemistry</subject><subject>Receptors, Purinergic P2 - genetics</subject><subject>Receptors, Purinergic P2 - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>signaling</subject><subject>somatotrophs</subject><subject>Vertebrates: endocrinology</subject><issn>1043-2760</issn><issn>1879-3061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMorl8_QelBRA_VmSZp2pPo4hcIHtRzSNPpEum2a9KK--9t3RW9eZo5PO_My8PYIcI5AqYXzwiCx4lK4RTwDIBnKuYbbAczlcccUtwc9h9kwnZDeANAkaHcZhNEnqtUqB12_exmjaldM4uKZUSfnTeW6rqvjY-a3tbUdq6kELkmMk1H3rU-Wriud53xy2hEwz7bqkwd6GA999jr7c3L9D5-fLp7mF49xlYC72ISZZ4YrJTNk0IAZFRJKDHhqZWFKGwhywqFEapQPMuzoV9pDdjCCKykVJLvsZPV3YVv33sKnZ67MDYwDbV90ApykFKoAZQr0Po2BE-VXng3H_pqBD3K09_y9GhGA-pveZoPuaP1g76YU_mbWtsagOM1YII1deVNY134cz1PkI_Y5QqjwcaHI6-DddRYKp0n2-mydf80-QLEVIuD</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Stojilkovic, Stanko S</creator><creator>Koshimizu, Taka-aki</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Signaling by extracellular nucleotides in anterior pituitary cells</title><author>Stojilkovic, Stanko S ; Koshimizu, Taka-aki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-e4d92a1f7c92b4008ef50d1236c5b4bcb5df14a47b73898976dca0cba41f55753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Adenosine Triphosphate - secretion</topic><topic>Animals</topic><topic>anterior pituitary</topic><topic>ATP</topic><topic>Autocrine Communication</topic><topic>Biological and medical sciences</topic><topic>Calcium Signaling</topic><topic>extracellular nucleotides</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadotrophs</topic><topic>Heterotrimeric GTP-Binding Proteins - metabolism</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Humans</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Lactotophs</topic><topic>Paracrine Communication</topic><topic>Pituitary Gland, Anterior - cytology</topic><topic>Pituitary Gland, Anterior - metabolism</topic><topic>Pituitary Gland, Anterior - secretion</topic><topic>Receptors, Purinergic P1 - metabolism</topic><topic>Receptors, Purinergic P2 - chemistry</topic><topic>Receptors, Purinergic P2 - genetics</topic><topic>Receptors, Purinergic P2 - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>signaling</topic><topic>somatotrophs</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stojilkovic, Stanko S</creatorcontrib><creatorcontrib>Koshimizu, Taka-aki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in Endocrinology & Metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stojilkovic, Stanko S</au><au>Koshimizu, Taka-aki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Signaling by extracellular nucleotides in anterior pituitary cells</atitle><jtitle>Trends in Endocrinology & Metabolism</jtitle><addtitle>Trends Endocrinol Metab</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>12</volume><issue>5</issue><spage>218</spage><epage>225</epage><pages>218-225</pages><issn>1043-2760</issn><eissn>1879-3061</eissn><abstract>Pituitary cells secrete ATP, which acts as an autocrine and/or paracrine extracellular messenger on two families of purinergic receptors: G-protein-coupled P2Y receptors (P2YRs) and ion-conducting P2X receptors (P2XRs). Lactotrophs and GH
3-immortalized cells express the P2Y
2R subtype. Several P2XR subtypes are expressed in pituitary cells. Gonadotrophs and somatotrophs express P2X
2aR and P2X
2bR, which occur as heteromeric channels. Lactotrophs and GH
3 cells express one or more ion-conducting subtypes from among P2X
3R, P2X
4R and P2X
7R in homomeric form. Thyrotrophs and corticotrophs also express P2XRs, but their identification requires further study. Pituitary cells express purinergic P1 receptors, which are activated by adenosine. The A
1R subtype of these receptors is expressed in melanotrophs and GH
3 cells. In this review, we briefly discuss the expression and coupling of A
1R and P2Y
2R, and focus on the expression and Ca
2+ signaling of P2XRs.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>11397647</pmid><doi>10.1016/S1043-2760(01)00387-3</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenosine Triphosphate - metabolism Adenosine Triphosphate - secretion Animals anterior pituitary ATP Autocrine Communication Biological and medical sciences Calcium Signaling extracellular nucleotides Fundamental and applied biological sciences. Psychology Gonadotrophs Heterotrimeric GTP-Binding Proteins - metabolism Hormones and neuropeptides. Regulation Humans Hypothalamus. Hypophysis. Epiphysis. Urophysis Lactotophs Paracrine Communication Pituitary Gland, Anterior - cytology Pituitary Gland, Anterior - metabolism Pituitary Gland, Anterior - secretion Receptors, Purinergic P1 - metabolism Receptors, Purinergic P2 - chemistry Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism signaling somatotrophs Vertebrates: endocrinology |
| title | Signaling by extracellular nucleotides in anterior pituitary cells |
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