Examination of the oral mucosa and peripheral blood cells of patients with recurrent aphthous ulceration for human herpesvirus DNA
Objective. The purpose of this study was to exam the oral mucosa and peripheral blood cells of patients with recurrent aph-thous ulceration (RAU) for the presence of the following human herpesviruses: herpes simplex viruses 1 and 2, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, human...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2000-02, Vol.89 (2), p.193-198 |
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| creator | Brice, Sylvia L. Cook, Dennis Leahy, Maureen Huff, J.Clark Weston, William L. |
| description | Objective. The purpose of this study was to exam the oral mucosa and peripheral blood cells of patients with recurrent aph-thous ulceration (RAU) for the presence of the following human herpesviruses: herpes simplex viruses 1 and 2, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, human herpesvirus-6, and human herpesvirus-7. Study design. Fifty-eight subjects with RAU and 10 control subjects were recruited at an academic referral center and enrolled in this prospective, nonrandomized, case-controlled study. Each of the subjects with RAU was seen during an acute episode, and swab specimens from lesional (RAU-acute/lesion) and clinically normal (RAU-acute/normal) oral mucosa were obtained. Each of 2 subjects with RAU was evaluated during more than one acute episode. Three subjects with RAU were seen between active episodes, and swab specimens were taken from clinically normal (RAU-convalescent) oral mucosa. Swab specimens from clinically normal (control/normal) oral mucosa were obtained from the control subjects. Peripheral blood specimens were obtained from subjects with RAU and control subjects at the time the swab specimens were performed. Through use of polymerase chain reaction, all swab and peripheral blood specimens were examined for the presence of human herpesvirus DNA. Statistical significance was determined by means of χ2 analysis. Results. Herpes simplex virus and human herpesvirus-6 were found in a higher percentage of mucosal specimens from the control subjects (herpes simplex virus, 4/10; human herpesvirus-6, 5/9) than from the subjects with RAU (RAU-acute/lesion: 3/45 herpes simplex virus, 13/53 human herpesvirus-6; RAU-acute/normal: 7/48 herpes simplex virus, 9/53 human herpesvirus-6). No difference was demonstrated between RAU-acute/lesion, RAU-acute/normal, and RAU-convalescent mucosal specimens for any of the human herpesviruses. Different human herpesviruses were identified from individual subjects with RAU during subsequent episodes of disease. Epstein-Barr virus (6/35), human herpesvirus-6 (3/40), and human herpesvirus-7 (7/43) were detected in the peripheral blood mononuclear cells during acute RAU but not in RAU-convalescent or control peripheral blood mononuclear cells. Conclusions. The detection of human herpesvirus DNA from the oral mucosa and peripheral blood mononuclear cells of patients with RAU appears to represent normal viral shedding rather than a direct causal mechanism in this disorder. (Oral Surg Oral Med Or |
| doi_str_mv | 10.1067/moe.2000.102041 |
| format | Article |
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The purpose of this study was to exam the oral mucosa and peripheral blood cells of patients with recurrent aph-thous ulceration (RAU) for the presence of the following human herpesviruses: herpes simplex viruses 1 and 2, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, human herpesvirus-6, and human herpesvirus-7. Study design. Fifty-eight subjects with RAU and 10 control subjects were recruited at an academic referral center and enrolled in this prospective, nonrandomized, case-controlled study. Each of the subjects with RAU was seen during an acute episode, and swab specimens from lesional (RAU-acute/lesion) and clinically normal (RAU-acute/normal) oral mucosa were obtained. Each of 2 subjects with RAU was evaluated during more than one acute episode. Three subjects with RAU were seen between active episodes, and swab specimens were taken from clinically normal (RAU-convalescent) oral mucosa. Swab specimens from clinically normal (control/normal) oral mucosa were obtained from the control subjects. Peripheral blood specimens were obtained from subjects with RAU and control subjects at the time the swab specimens were performed. Through use of polymerase chain reaction, all swab and peripheral blood specimens were examined for the presence of human herpesvirus DNA. Statistical significance was determined by means of χ2 analysis. Results. Herpes simplex virus and human herpesvirus-6 were found in a higher percentage of mucosal specimens from the control subjects (herpes simplex virus, 4/10; human herpesvirus-6, 5/9) than from the subjects with RAU (RAU-acute/lesion: 3/45 herpes simplex virus, 13/53 human herpesvirus-6; RAU-acute/normal: 7/48 herpes simplex virus, 9/53 human herpesvirus-6). No difference was demonstrated between RAU-acute/lesion, RAU-acute/normal, and RAU-convalescent mucosal specimens for any of the human herpesviruses. Different human herpesviruses were identified from individual subjects with RAU during subsequent episodes of disease. Epstein-Barr virus (6/35), human herpesvirus-6 (3/40), and human herpesvirus-7 (7/43) were detected in the peripheral blood mononuclear cells during acute RAU but not in RAU-convalescent or control peripheral blood mononuclear cells. Conclusions. The detection of human herpesvirus DNA from the oral mucosa and peripheral blood mononuclear cells of patients with RAU appears to represent normal viral shedding rather than a direct causal mechanism in this disorder. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89:193-8)</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1067/moe.2000.102041</identifier><identifier>PMID: 10673655</identifier><language>eng</language><publisher>St. Louis, MO: Mosby, Inc</publisher><subject>Adult ; Biological and medical sciences ; Biotechnology ; Case-Control Studies ; Chi-Square Distribution ; Dentistry ; DNA, Viral - analysis ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic engineering ; Genetic technics ; Herpesviridae - isolation & purification ; Herpesviridae - pathogenicity ; Humans ; In vitro gene amplification. Pcr technique ; Leukocytes, Mononuclear - virology ; Male ; Medical sciences ; Methods. Procedures. Technologies ; Mouth Mucosa - virology ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Polymerase Chain Reaction ; Prospective Studies ; Stomatitis, Aphthous - virology ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology ; Viremia - diagnosis</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2000-02, Vol.89 (2), p.193-198</ispartof><rights>2000 Mosby, Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-1482019d76250d295e1a6ee60fb208a326d9330562d865fafcea1af125061073</citedby><cites>FETCH-LOGICAL-c372t-1482019d76250d295e1a6ee60fb208a326d9330562d865fafcea1af125061073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1079210400849999$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1274362$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10673655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brice, Sylvia L.</creatorcontrib><creatorcontrib>Cook, Dennis</creatorcontrib><creatorcontrib>Leahy, Maureen</creatorcontrib><creatorcontrib>Huff, J.Clark</creatorcontrib><creatorcontrib>Weston, William L.</creatorcontrib><title>Examination of the oral mucosa and peripheral blood cells of patients with recurrent aphthous ulceration for human herpesvirus DNA</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Objective. The purpose of this study was to exam the oral mucosa and peripheral blood cells of patients with recurrent aph-thous ulceration (RAU) for the presence of the following human herpesviruses: herpes simplex viruses 1 and 2, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, human herpesvirus-6, and human herpesvirus-7. Study design. Fifty-eight subjects with RAU and 10 control subjects were recruited at an academic referral center and enrolled in this prospective, nonrandomized, case-controlled study. Each of the subjects with RAU was seen during an acute episode, and swab specimens from lesional (RAU-acute/lesion) and clinically normal (RAU-acute/normal) oral mucosa were obtained. Each of 2 subjects with RAU was evaluated during more than one acute episode. Three subjects with RAU were seen between active episodes, and swab specimens were taken from clinically normal (RAU-convalescent) oral mucosa. Swab specimens from clinically normal (control/normal) oral mucosa were obtained from the control subjects. Peripheral blood specimens were obtained from subjects with RAU and control subjects at the time the swab specimens were performed. Through use of polymerase chain reaction, all swab and peripheral blood specimens were examined for the presence of human herpesvirus DNA. Statistical significance was determined by means of χ2 analysis. Results. Herpes simplex virus and human herpesvirus-6 were found in a higher percentage of mucosal specimens from the control subjects (herpes simplex virus, 4/10; human herpesvirus-6, 5/9) than from the subjects with RAU (RAU-acute/lesion: 3/45 herpes simplex virus, 13/53 human herpesvirus-6; RAU-acute/normal: 7/48 herpes simplex virus, 9/53 human herpesvirus-6). No difference was demonstrated between RAU-acute/lesion, RAU-acute/normal, and RAU-convalescent mucosal specimens for any of the human herpesviruses. Different human herpesviruses were identified from individual subjects with RAU during subsequent episodes of disease. Epstein-Barr virus (6/35), human herpesvirus-6 (3/40), and human herpesvirus-7 (7/43) were detected in the peripheral blood mononuclear cells during acute RAU but not in RAU-convalescent or control peripheral blood mononuclear cells. Conclusions. The detection of human herpesvirus DNA from the oral mucosa and peripheral blood mononuclear cells of patients with RAU appears to represent normal viral shedding rather than a direct causal mechanism in this disorder. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89:193-8)</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Dentistry</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic engineering</subject><subject>Genetic technics</subject><subject>Herpesviridae - isolation & purification</subject><subject>Herpesviridae - pathogenicity</subject><subject>Humans</subject><subject>In vitro gene amplification. Pcr technique</subject><subject>Leukocytes, Mononuclear - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methods. Procedures. Technologies</subject><subject>Mouth Mucosa - virology</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polymerase Chain Reaction</subject><subject>Prospective Studies</subject><subject>Stomatitis, Aphthous - virology</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><subject>Viremia - diagnosis</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1v1TAUhi0EoqUwsyEPiC2tP2LneqxK-ZAqWDqwWb72sWKUxMFOCqz8ck7IlWBhso_1vK-OH0JecnbJme6uxgyXgrFtEqzlj8g5V-LQSKO-PMY760wjOGvPyLNavyKnpTFPydmWlVqpc_Lr9ocb0-SWlCeaI116oLm4gY6rz9VRNwU6Q0lzD9vrccg5UA_DUDd6xhxMS6Xf09LTAn4tBWfq5n7p81rpOnjM_SmPudB-Hd1EsWqG-pAKAm8_XT8nT6IbKrw4nRfk_t3t_c2H5u7z-48313eNl51YGt4eBOMmdFooFoRRwJ0G0CweBTs4KXQwUjKlRThoFV304LiLHGmNIuQFebPXziV_W6Eudkx1-4mbAFe1HTNMcdkieLWDvuRaC0Q7lzS68tNyZjdzFq3bzbrdrWPi1al6PY4Q_uF3zQi8PgGuejfE4iaf6l9OdK3UAjGzY4AaHhIUWz369RASul1syOm_O_wG0wqfAA</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Brice, Sylvia L.</creator><creator>Cook, Dennis</creator><creator>Leahy, Maureen</creator><creator>Huff, J.Clark</creator><creator>Weston, William L.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>Examination of the oral mucosa and peripheral blood cells of patients with recurrent aphthous ulceration for human herpesvirus DNA</title><author>Brice, Sylvia L. ; Cook, Dennis ; Leahy, Maureen ; Huff, J.Clark ; Weston, William L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-1482019d76250d295e1a6ee60fb208a326d9330562d865fafcea1af125061073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Dentistry</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic engineering</topic><topic>Genetic technics</topic><topic>Herpesviridae - isolation & purification</topic><topic>Herpesviridae - pathogenicity</topic><topic>Humans</topic><topic>In vitro gene amplification. Pcr technique</topic><topic>Leukocytes, Mononuclear - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methods. Procedures. Technologies</topic><topic>Mouth Mucosa - virology</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polymerase Chain Reaction</topic><topic>Prospective Studies</topic><topic>Stomatitis, Aphthous - virology</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><topic>Viremia - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brice, Sylvia L.</creatorcontrib><creatorcontrib>Cook, Dennis</creatorcontrib><creatorcontrib>Leahy, Maureen</creatorcontrib><creatorcontrib>Huff, J.Clark</creatorcontrib><creatorcontrib>Weston, William L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brice, Sylvia L.</au><au>Cook, Dennis</au><au>Leahy, Maureen</au><au>Huff, J.Clark</au><au>Weston, William L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Examination of the oral mucosa and peripheral blood cells of patients with recurrent aphthous ulceration for human herpesvirus DNA</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>89</volume><issue>2</issue><spage>193</spage><epage>198</epage><pages>193-198</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Objective. The purpose of this study was to exam the oral mucosa and peripheral blood cells of patients with recurrent aph-thous ulceration (RAU) for the presence of the following human herpesviruses: herpes simplex viruses 1 and 2, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, human herpesvirus-6, and human herpesvirus-7. Study design. Fifty-eight subjects with RAU and 10 control subjects were recruited at an academic referral center and enrolled in this prospective, nonrandomized, case-controlled study. Each of the subjects with RAU was seen during an acute episode, and swab specimens from lesional (RAU-acute/lesion) and clinically normal (RAU-acute/normal) oral mucosa were obtained. Each of 2 subjects with RAU was evaluated during more than one acute episode. Three subjects with RAU were seen between active episodes, and swab specimens were taken from clinically normal (RAU-convalescent) oral mucosa. Swab specimens from clinically normal (control/normal) oral mucosa were obtained from the control subjects. Peripheral blood specimens were obtained from subjects with RAU and control subjects at the time the swab specimens were performed. Through use of polymerase chain reaction, all swab and peripheral blood specimens were examined for the presence of human herpesvirus DNA. Statistical significance was determined by means of χ2 analysis. Results. Herpes simplex virus and human herpesvirus-6 were found in a higher percentage of mucosal specimens from the control subjects (herpes simplex virus, 4/10; human herpesvirus-6, 5/9) than from the subjects with RAU (RAU-acute/lesion: 3/45 herpes simplex virus, 13/53 human herpesvirus-6; RAU-acute/normal: 7/48 herpes simplex virus, 9/53 human herpesvirus-6). No difference was demonstrated between RAU-acute/lesion, RAU-acute/normal, and RAU-convalescent mucosal specimens for any of the human herpesviruses. Different human herpesviruses were identified from individual subjects with RAU during subsequent episodes of disease. Epstein-Barr virus (6/35), human herpesvirus-6 (3/40), and human herpesvirus-7 (7/43) were detected in the peripheral blood mononuclear cells during acute RAU but not in RAU-convalescent or control peripheral blood mononuclear cells. Conclusions. The detection of human herpesvirus DNA from the oral mucosa and peripheral blood mononuclear cells of patients with RAU appears to represent normal viral shedding rather than a direct causal mechanism in this disorder. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89:193-8)</abstract><cop>St. Louis, MO</cop><pub>Mosby, Inc</pub><pmid>10673655</pmid><doi>10.1067/moe.2000.102041</doi><tpages>6</tpages></addata></record> |
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| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2000-02, Vol.89 (2), p.193-198 |
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| subjects | Adult Biological and medical sciences Biotechnology Case-Control Studies Chi-Square Distribution Dentistry DNA, Viral - analysis Female Fundamental and applied biological sciences. Psychology Genetic engineering Genetic technics Herpesviridae - isolation & purification Herpesviridae - pathogenicity Humans In vitro gene amplification. Pcr technique Leukocytes, Mononuclear - virology Male Medical sciences Methods. Procedures. Technologies Mouth Mucosa - virology Non tumoral diseases Otorhinolaryngology. Stomatology Polymerase Chain Reaction Prospective Studies Stomatitis, Aphthous - virology Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Viremia - diagnosis |
| title | Examination of the oral mucosa and peripheral blood cells of patients with recurrent aphthous ulceration for human herpesvirus DNA |
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