Glycemic control and heart failure among adult patients with diabetes
Glycemic control is associated with microvascular events, but its effect on the risk of heart failure is not well understood. We examined the association between hemoglobin (Hb) A(Ic) and the risk of heart failure hospitalization and/or death in a population-based sample of adult patients with diabe...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2001-06, Vol.103 (22), p.2668-2673 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | IRIBARREN, Carlos KARTER, Andrew J GO, Alan S FERRARA, Assiamira LIU, Jennifer Y SIDNEY, Stephen SELBY, Joseph V |
| description | Glycemic control is associated with microvascular events, but its effect on the risk of heart failure is not well understood. We examined the association between hemoglobin (Hb) A(Ic) and the risk of heart failure hospitalization and/or death in a population-based sample of adult patients with diabetes and assessed whether this association differed by patient sex, heart failure pathogenesis, and hypertension status.
A cohort design was used with baseline between January 1, 1995, and June 30, 1996, and follow-up through December 31, 1997 (median 2.2 years). Participants were 25 958 men and 22 900 women with (predominantly type 2) diabetes, >/=19 years old, with no known history of heart failure. There were a total of 935 events (516 among men; 419 among women). After adjustment for age, sex, race/ethnicity, education level, cigarette smoking, alcohol consumption, hypertension, obesity, use of beta-blockers and ACE inhibitors, type and duration of diabetes, and incidence of interim myocardial infarction, each 1% increase in Hb A(Ic) was associated with an 8% increased risk of heart failure (95% CI 5% to 12%). An Hb A(Ic) >/=10, relative to Hb A(Ic) |
| doi_str_mv | 10.1161/01.CIR.103.22.2668 |
| format | Article |
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A cohort design was used with baseline between January 1, 1995, and June 30, 1996, and follow-up through December 31, 1997 (median 2.2 years). Participants were 25 958 men and 22 900 women with (predominantly type 2) diabetes, >/=19 years old, with no known history of heart failure. There were a total of 935 events (516 among men; 419 among women). After adjustment for age, sex, race/ethnicity, education level, cigarette smoking, alcohol consumption, hypertension, obesity, use of beta-blockers and ACE inhibitors, type and duration of diabetes, and incidence of interim myocardial infarction, each 1% increase in Hb A(Ic) was associated with an 8% increased risk of heart failure (95% CI 5% to 12%). An Hb A(Ic) >/=10, relative to Hb A(Ic) <7, was associated with 1.56-fold (95% CI 1.26 to 1.93) greater risk of heart failure. Although the association was stronger in men than in women, no differences existed by heart failure pathogenesis or hypertension status.
These results confirm previous evidence that poor glycemic control may be associated with an increased risk of heart failure among adult patients with diabetes.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.103.22.2668</identifier><identifier>PMID: 11390335</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Age Factors ; Aged ; Biological and medical sciences ; Blood Glucose - metabolism ; Cardiology. Vascular system ; Cohort Studies ; Diabetes Complications ; Female ; Follow-Up Studies ; Glycated Hemoglobin A - metabolism ; Heart ; Heart Diseases - blood ; Heart Diseases - etiology ; Heart Diseases - mortality ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Hospitalization - statistics & numerical data ; Humans ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Sex Factors ; Survival Rate</subject><ispartof>Circulation (New York, N.Y.), 2001-06, Vol.103 (22), p.2668-2673</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jun 5, 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-a90f6541f913370661bf8841d8824c665aad8c73605a0bec956789ac333fe2b03</citedby><cites>FETCH-LOGICAL-c491t-a90f6541f913370661bf8841d8824c665aad8c73605a0bec956789ac333fe2b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3685,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1050813$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11390335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IRIBARREN, Carlos</creatorcontrib><creatorcontrib>KARTER, Andrew J</creatorcontrib><creatorcontrib>GO, Alan S</creatorcontrib><creatorcontrib>FERRARA, Assiamira</creatorcontrib><creatorcontrib>LIU, Jennifer Y</creatorcontrib><creatorcontrib>SIDNEY, Stephen</creatorcontrib><creatorcontrib>SELBY, Joseph V</creatorcontrib><title>Glycemic control and heart failure among adult patients with diabetes</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Glycemic control is associated with microvascular events, but its effect on the risk of heart failure is not well understood. We examined the association between hemoglobin (Hb) A(Ic) and the risk of heart failure hospitalization and/or death in a population-based sample of adult patients with diabetes and assessed whether this association differed by patient sex, heart failure pathogenesis, and hypertension status.
A cohort design was used with baseline between January 1, 1995, and June 30, 1996, and follow-up through December 31, 1997 (median 2.2 years). Participants were 25 958 men and 22 900 women with (predominantly type 2) diabetes, >/=19 years old, with no known history of heart failure. There were a total of 935 events (516 among men; 419 among women). After adjustment for age, sex, race/ethnicity, education level, cigarette smoking, alcohol consumption, hypertension, obesity, use of beta-blockers and ACE inhibitors, type and duration of diabetes, and incidence of interim myocardial infarction, each 1% increase in Hb A(Ic) was associated with an 8% increased risk of heart failure (95% CI 5% to 12%). An Hb A(Ic) >/=10, relative to Hb A(Ic) <7, was associated with 1.56-fold (95% CI 1.26 to 1.93) greater risk of heart failure. Although the association was stronger in men than in women, no differences existed by heart failure pathogenesis or hypertension status.
These results confirm previous evidence that poor glycemic control may be associated with an increased risk of heart failure among adult patients with diabetes.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Cohort Studies</subject><subject>Diabetes Complications</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Heart</subject><subject>Heart Diseases - blood</subject><subject>Heart Diseases - etiology</subject><subject>Heart Diseases - mortality</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Sex Factors</subject><subject>Survival Rate</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1rFTEQhkNR2mP1D3ghQcS7XWeSzdelHGotFIRSr8NsNmu37McxyVL6791DDyheDQPP-zDzMvYeoUbU-AWw3t_c1QiyFqIWWtsztkMlmqpR0r1iOwBwlZFCXLA3OT9uq5ZGnbMLROlASrVjV9fjc4jTEHhY5pKWkdPc8YdIqfCehnFNkdO0zL84detY-IHKEOeS-dNQHng3UBtLzG_Z657GHN-d5iX7-e3qfv-9uv1xfbP_eluFxmGpyEGvVYO9QykNaI1tb22DnbWiCVoros4GIzUogjYGp7SxjoKUso-iBXnJPr94D2n5vcZc_DTkEMeR5ris2Rtw0FhjNvDjf-DjsqZ5u80LFEZa1EebeIFCWnJOsfeHNEyUnj2CPzbsAf3W8LZKL4Q_NryFPpzMazvF7m_kVOkGfDoBlAONfaI5DPkftQK7vf8HRh6BiA</recordid><startdate>20010605</startdate><enddate>20010605</enddate><creator>IRIBARREN, Carlos</creator><creator>KARTER, Andrew J</creator><creator>GO, Alan S</creator><creator>FERRARA, Assiamira</creator><creator>LIU, Jennifer Y</creator><creator>SIDNEY, Stephen</creator><creator>SELBY, Joseph V</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20010605</creationdate><title>Glycemic control and heart failure among adult patients with diabetes</title><author>IRIBARREN, Carlos ; KARTER, Andrew J ; GO, Alan S ; FERRARA, Assiamira ; LIU, Jennifer Y ; SIDNEY, Stephen ; SELBY, Joseph V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-a90f6541f913370661bf8841d8824c665aad8c73605a0bec956789ac333fe2b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Cohort Studies</topic><topic>Diabetes Complications</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Heart</topic><topic>Heart Diseases - blood</topic><topic>Heart Diseases - etiology</topic><topic>Heart Diseases - mortality</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Sex Factors</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IRIBARREN, Carlos</creatorcontrib><creatorcontrib>KARTER, Andrew J</creatorcontrib><creatorcontrib>GO, Alan S</creatorcontrib><creatorcontrib>FERRARA, Assiamira</creatorcontrib><creatorcontrib>LIU, Jennifer Y</creatorcontrib><creatorcontrib>SIDNEY, Stephen</creatorcontrib><creatorcontrib>SELBY, Joseph V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IRIBARREN, Carlos</au><au>KARTER, Andrew J</au><au>GO, Alan S</au><au>FERRARA, Assiamira</au><au>LIU, Jennifer Y</au><au>SIDNEY, Stephen</au><au>SELBY, Joseph V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycemic control and heart failure among adult patients with diabetes</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2001-06-05</date><risdate>2001</risdate><volume>103</volume><issue>22</issue><spage>2668</spage><epage>2673</epage><pages>2668-2673</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Glycemic control is associated with microvascular events, but its effect on the risk of heart failure is not well understood. We examined the association between hemoglobin (Hb) A(Ic) and the risk of heart failure hospitalization and/or death in a population-based sample of adult patients with diabetes and assessed whether this association differed by patient sex, heart failure pathogenesis, and hypertension status.
A cohort design was used with baseline between January 1, 1995, and June 30, 1996, and follow-up through December 31, 1997 (median 2.2 years). Participants were 25 958 men and 22 900 women with (predominantly type 2) diabetes, >/=19 years old, with no known history of heart failure. There were a total of 935 events (516 among men; 419 among women). After adjustment for age, sex, race/ethnicity, education level, cigarette smoking, alcohol consumption, hypertension, obesity, use of beta-blockers and ACE inhibitors, type and duration of diabetes, and incidence of interim myocardial infarction, each 1% increase in Hb A(Ic) was associated with an 8% increased risk of heart failure (95% CI 5% to 12%). An Hb A(Ic) >/=10, relative to Hb A(Ic) <7, was associated with 1.56-fold (95% CI 1.26 to 1.93) greater risk of heart failure. Although the association was stronger in men than in women, no differences existed by heart failure pathogenesis or hypertension status.
These results confirm previous evidence that poor glycemic control may be associated with an increased risk of heart failure among adult patients with diabetes.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11390335</pmid><doi>10.1161/01.CIR.103.22.2668</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete - AutoHoldings; EZB-FREE-00999 freely available EZB journals |
| subjects | Age Factors Aged Biological and medical sciences Blood Glucose - metabolism Cardiology. Vascular system Cohort Studies Diabetes Complications Female Follow-Up Studies Glycated Hemoglobin A - metabolism Heart Heart Diseases - blood Heart Diseases - etiology Heart Diseases - mortality Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hospitalization - statistics & numerical data Humans Male Medical sciences Middle Aged Multivariate Analysis Sex Factors Survival Rate |
| title | Glycemic control and heart failure among adult patients with diabetes |
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