Phospholipid Flippase Activity of the Reconstituted P-Glycoprotein Multidrug Transporter

The P-glycoprotein multidrug transporter acts as an ATP-powered efflux pump for a large variety of hydrophobic drugs, natural products, and peptides. The protein is proposed to interact with its substrates within the hydrophobic interior of the membrane. There is indirect evidence to suggest that P-...

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Veröffentlicht in:	Biochemistry (Easton) 2001-06, Vol.40 (23), p.6937-6947
Hauptverfasser:	Romsicki, Yolanda, Sharom, Frances J
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Chloro-7-nitrobenzofurazan - metabolism Animals ATP Binding Cassette Transporter, Subfamily B - metabolism ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ATP-Binding Cassette Transporters - metabolism Binding, Competitive Biological Transport Carrier Proteins - metabolism CHO Cells Cholic Acids Cricetinae Detergents Dithionite - metabolism Drug Resistance, Multiple Liposomes - metabolism Membrane Proteins - metabolism Phosphatidylcholines - metabolism Phospholipid Transfer Proteins Phospholipids - metabolism Proteolipids - metabolism Spectrometry, Fluorescence Substrate Specificity
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