α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans
The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of alpha-adrenergic coronary vasomotion in humans. Confirming prior animal experiments, there is no evidence of alpha-adrenergic coronary constrictor tone at rest. Again confirming pr...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2000-02, Vol.101 (6), p.689-694 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | HEUSCH, G BAUMGART, D CAMICI, P CHILIAN, W GREGORINI, L HESS, O INDOLFI, C RIMOLDI, O |
| description | The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of alpha-adrenergic coronary vasomotion in humans. Confirming prior animal experiments, there is no evidence of alpha-adrenergic coronary constrictor tone at rest. Again confirming prior experiments, responses to alpha-adrenoceptor activation are augmented in the presence of coronary endothelial dysfunction and atherosclerosis, involving both alpha(1)- and alpha(2)-adrenoceptors in epicardial conduit arteries and microvessels. Such augmented alpha-adrenergic coronary constriction is observed during exercise and coronary interventions, and it is powerful enough to induce myocardial ischemia and limit myocardial function. Recent studies indicate a genetic determination of alpha(2)-adrenergic coronary constriction. |
| doi_str_mv | 10.1161/01.CIR.101.6.689 |
| format | Article |
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Confirming prior animal experiments, there is no evidence of alpha-adrenergic coronary constrictor tone at rest. Again confirming prior experiments, responses to alpha-adrenoceptor activation are augmented in the presence of coronary endothelial dysfunction and atherosclerosis, involving both alpha(1)- and alpha(2)-adrenoceptors in epicardial conduit arteries and microvessels. Such augmented alpha-adrenergic coronary constriction is observed during exercise and coronary interventions, and it is powerful enough to induce myocardial ischemia and limit myocardial function. Recent studies indicate a genetic determination of alpha(2)-adrenergic coronary constriction.</description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - physiopathology</subject><subject>Heart</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Receptors, Adrenergic, alpha - physiology</subject><subject>Vasoconstriction</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1KAzEUhYMotlb3rmQW4m7G_M2dmWUp_hQKgug6ZJKMjcwkNekIfSxfxGcy0oKuLufyncO9B6FLggtCgNxiUiyWzwVJEwqomyM0JSXlOS9Zc4ymGOMmrxilE3QW43uSwKryFE0IhrQGNkXL7698roNxJrxZlSkfvJNhl33K6JV3cRus2lrvMul0Nuy8kkFb2Wc2qrUZrMysy9bjIF08Ryed7KO5OMwZer2_e1k85qunh-VivsoVJ2ybM5ANp21juOEdSM5qXncYoGuppoqDZlxrqXVVd6zlqgIFxDSat4qShpXAZuhmn7sJ_mM0cSuGdIzpe-mMH6OocIM58DqBeA-q4GMMphObYIf0nCBY_NYnMBGpviSJAJHqS5arQ_bYDkb_M-z7SsD1AZBRyb4L0ikb_zhaYYpL9gNWenj-</recordid><startdate>20000215</startdate><enddate>20000215</enddate><creator>HEUSCH, G</creator><creator>BAUMGART, D</creator><creator>CAMICI, P</creator><creator>CHILIAN, W</creator><creator>GREGORINI, L</creator><creator>HESS, O</creator><creator>INDOLFI, C</creator><creator>RIMOLDI, O</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000215</creationdate><title>α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans</title><author>HEUSCH, G ; BAUMGART, D ; CAMICI, P ; CHILIAN, W ; GREGORINI, L ; HESS, O ; INDOLFI, C ; RIMOLDI, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-36a942b9e4e4f6a43848f066fb2d2c46d34ddadd78f3b4c76c61e9d4bc2193563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - physiopathology</topic><topic>Heart</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Receptors, Adrenergic, alpha - physiology</topic><topic>Vasoconstriction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HEUSCH, G</creatorcontrib><creatorcontrib>BAUMGART, D</creatorcontrib><creatorcontrib>CAMICI, P</creatorcontrib><creatorcontrib>CHILIAN, W</creatorcontrib><creatorcontrib>GREGORINI, L</creatorcontrib><creatorcontrib>HESS, O</creatorcontrib><creatorcontrib>INDOLFI, C</creatorcontrib><creatorcontrib>RIMOLDI, O</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HEUSCH, G</au><au>BAUMGART, D</au><au>CAMICI, P</au><au>CHILIAN, W</au><au>GREGORINI, L</au><au>HESS, O</au><au>INDOLFI, C</au><au>RIMOLDI, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2000-02-15</date><risdate>2000</risdate><volume>101</volume><issue>6</issue><spage>689</spage><epage>694</epage><pages>689-694</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of alpha-adrenergic coronary vasomotion in humans. 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| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2000-02, Vol.101 (6), p.689-694 |
| issn | 0009-7322 1524-4539 |
| language | eng |
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| source | MEDLINE; EZB Electronic Journals Library; American Heart Association; Journals@Ovid Complete |
| subjects | Biological and medical sciences Cardiology. Vascular system Coronary heart disease Coronary Vessels - physiopathology Heart Humans Medical sciences Myocardial Ischemia - physiopathology Receptors, Adrenergic, alpha - physiology Vasoconstriction |
| title | α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans |
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