AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension

To separate the role of ANG II from pressure in hypertrophy of the vascular wall in one-kidney, one-clip (1K1C) hypertension, experimental and sham-operated rats were given the AT(1)-receptor antagonist losartan (20 mg x kg(-1) x day(-1)) or tap water for 14 days. Mean arterial pressure was elevated...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2000-02, Vol.278 (2), p.H613-H622
Hauptverfasser:	Parker, S B, Dobrian, A D, Wade, S S, Prewitt, R L
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Receptor Antagonists Animals Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Arteries - metabolism Arteries - pathology Blood Pressure Bromodeoxyuridine - pharmacokinetics Capillaries - pathology Carotid Arteries - metabolism Carotid Arteries - pathology Hypertension, Renal - metabolism Hypertension, Renal - pathology Hypertension, Renal - physiopathology Hypertrophy Losartan - pharmacology Male Mesenteric Arteries - metabolism Mesenteric Arteries - pathology Platelet-Derived Growth Factor - genetics Platelet-Derived Growth Factor - metabolism Rats Rats, Wistar Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Reference Values RNA, Messenger - metabolism
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