Morphological and Physiological Restorations of Hereditary Form of Dilated Cardiomyopathy by Somatic Gene Therapy

TO-2 strain hamsters with dilated cardiomyopathy, gene deletion of δ-sarcoglycan (SG) and no expression of α-, β-, γ-, and δ-SG proteins are useful for developing the potential gene therapy of intractable heart failure. We prepared recombinant adeno-associated virus vector including normal δ-SG gene...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2001-06, Vol.284 (2), p.431-435
Hauptverfasser:	Kawada, Tomie, Sakamoto, Aiji, Nakazawa, Mikio, Urabe, Masashi, Masuda, Fujiko, Hemmi, Chieko, Wang, Yue, Soo Shin, Wee, Nakatsuru, Yoko, Sato, Hiroshi, Ozawa, Keiya, Toyo-oka, Teruhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Animals beta-Galactosidase - biosynthesis beta-Galactosidase - genetics cardiomyopathy Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - pathology Cardiomyopathy, Dilated - therapy Cell Size - drug effects Cricetinae Cytomegalovirus Cytoskeletal Proteins - administration & dosage Cytoskeletal Proteins - deficiency Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism d-sarcoglycan Dependovirus - genetics Disease Models, Animal Dystrophin - metabolism Gene Expression - drug effects gene therapy Genes, Reporter Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Genetic Vectors - metabolism Heart - drug effects heart failure hemodynamics Hemodynamics - drug effects Injections - methods Male Membrane Glycoproteins - administration & dosage Membrane Glycoproteins - deficiency Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Myocardium - metabolism Myocardium - pathology Sarcoglycans Transfection Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!