Heterosubtypic immunity to influenza A virus in mice lacking IgA, all Ig, NKT cells, or gamma delta T cells

The mechanisms of broad cross-protection to influenza viruses of different subtypes, termed heterosubtypic immunity, remain incompletely understood. We used knockout mouse strains to examine the potential for heterosubtypic immunity in mice lacking IgA, all Ig and B cells, NKT cells (CD1 knockout mi...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-06, Vol.166 (12), p.7437-7445
Hauptverfasser:	Benton, K A, Misplon, J A, Lo, C Y, Brutkiewicz, R R, Prasad, S A, Epstein, S L
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals CD1 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Female IgA Deficiency - genetics IgA Deficiency - immunology Immunoglobulins - deficiency Immunoglobulins - genetics Influenza A virus Killer Cells, Natural - immunology Lung - immunology Lung - virology Lymphocyte Depletion Male Mice Mice, Knockout Orthomyxoviridae - immunology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Receptors, Antigen, T-Cell, gamma-delta - deficiency Receptors, Antigen, T-Cell, gamma-delta - genetics Respiratory System - immunology Respiratory System - virology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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